104069-95-6

Usage

Chemical class

1,8-Naphthyridine-3-carboxylic acids

Derived from

Ethyl esters

Structural features

a. Fluorine-substituted phenyl group
b. Piperazine moiety
c. Oxo group

Potential applications

a. Pharmaceutical industry
b. Precursor or intermediate in the synthesis of other pharmaceutical compounds

Possible pharmacological activities

a. Antimicrobial
b. Antiviral
c. Anticancer

Research status

Further research needed to fully understand its potential uses and effects.

Upstream product

• 110-85-0 piperazine 
• 100491-30-3 ethyl 7-chloro-1-(4-fluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 100491-00-7 ethyl 3-p-fluoroanilino-2-(2,6-dichloro-5-fluoronicotinyl)acrylate 
• 82671-03-2 ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate 
• 82671-06-5 2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid 
• 96568-02-4 2,6-dichloro-5-fluoro-3-nicotinoyl chloride 
• 96568-04-6 ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate 

Downstream Products

• 104069-96-7 6-Fluoro-1-(4-fluoro-phenyl)-4-oxo-7-piperazin-1-yl-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid; hydrochloride 

Relevant academic research and scientific papers

Synthesis and Structure-Activity Relationships of New Arylfluoronaphthyridine Antibacterial Agents

Novel arylfluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid have been prepared and their antibacterial activity evaluated.These derivatives are characterized by having a fluorine atom at 6-position, substituted amino groups at the 7-position, and substituted phenyl groups at the 1-position.The in vitro antibacterial potency is greatest when the 1-substituent is either p-fluorophenyl or o,p-difluorophenyl and the 7-substituent is a 3-amino-1-pyrrolidinyl group. 1-(2,4-Difluorophenyl)-6-fluoro-7-(3-amino-1-pyrrolidinyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (38) was found to possess excellent in vitro potency and in vivo efficacy.