10407-11-1

Basic information

• Product Name: N-(2-BROMO-BENZYLIDENE)-N'-PHENYL-HYDRAZINE
• Synonyms: N-(2-BROMO-BENZYLIDENE)-N'-PHENYL-HYDRAZINE;2-Bromobenzaldehyde phenyl hydrazone
• CAS NO: 10407-11-1
• Molecular Formula: C₁₃H₁₁BrN₂
• Molecular Weight: 275.14384
• Mol File: 10407-11-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2-BROMO-BENZYLIDENE)-N'-PHENYL-HYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-BROMO-BENZYLIDENE)-N'-PHENYL-HYDRAZINE(10407-11-1)
• EPA Substance Registry System: N-(2-BROMO-BENZYLIDENE)-N'-PHENYL-HYDRAZINE(10407-11-1)

Safety Data

• Hazardous Substances Data: 10407-11-1(Hazardous Substances Data)

Upstream product

• 100-63-0 phenylhydrazine 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 138479-62-6 2-(indazol-1'-yl)benzophenone 
• 138479-43-3 1-[2-(1H-indazol-1-yl)phenyl]ethan-1-one 
• 138479-50-2 2-(1H-indazol-1-yl)benzaldehyde 

Relevant articles and documents

Syntheses and evaluation of benzodiazaborine compounds against M. tuberculosis H37R(v) in vitro

The synthesis of six benzo[e]diazaborine compounds and their in vitro evaluation against M. tuberculosis H37R(v) is described. The compounds 1,2-dihydro-1-hydroxy-2-phenyl-2,4,1-benzo[e]diazaborin-3(4H)-one, 4, and 1,2-dihydro-1-hydroxy-2-(3-pyridyl)-2,4,1-benzo[e]diazaborin-3(4H)-thione, (5), showed the greatest inhibitory activity.

Stereospecific copper(II)-catalyzed tandem ring opening/oxidative alkylation of donor-acceptor cyclopropanes with hydrazones: Synthesis of tetrahydropyridazines

Aerobic copper(II)-catalyzed tandem ring opening and oxidative C-H alkylation of donor-acceptor cyclopropanes with bisaryl hydrazones is accomplished to produce tetrahydropyridazines, in which copper(II) plays dual role as a Lewis acid as well as redox catalyst. The reaction is stereospecific, and optically active cyclopropanes can be reacted with high optical purities (89-98% enantiomeric excess). The substrate scope, functional group tolerance, dual role of the copper(II) catalyst, and the use of air as an oxidant are the important practical features. A product bearing a 3-bromoaryl group can be subjected to Pd-catalyzed Suzuki coupling with boronic acid in high yield.

Synthesis of substituted 1 H-indazoles from arynes and hydrazones

The 1H-indazole skeleton can be constructed by a [3 + 2] annulation approach from arynes and hydrazones. Under different reaction conditions, both N-tosylhydrazones and N-aryl/alkylhydrazones can be used to afford a variety of indazoles. The former reaction affords 3-substituted indazoles either via in situ generated diazo compounds or through an annulation/elimination process. The latter reaction leads to 1,3-disubstituted indazoles likely through an annulation/oxidation process. The reactions operate under mild conditions and can accommodate aryl, vinyl, and less satisfactorily, alkyl groups.