104071-89-8Relevant academic research and scientific papers
Functional and mechanistic analyses of biomimetic aminoacyl transfer reactions in de novo designed coiled coil peptides via rational active site engineering
Leman, Luke J.,Weinberger, Dana A.,Huang, Zheng-Zheng,Wilcoxen, Keith M.,Ghadiri, M. Reza
, p. 2959 - 2966 (2007/10/03)
Ribosomes and nonribosomal peptide synthetases (NRPSs) carry out instructed peptide synthesis through a series of directed intermodular aminoacyl transfer reactions. We recently reported the design of coiled-coil assemblies that could functionally mimic t
Biomimetic catalysis of intermodular aminoacyl transfer
Wilcoxen, Keith M.,Leman, Luke J.,Weinberger, Dana A.,Huang, Zheng-Zheng,Ghadiri, M. Reza
, p. 748 - 749 (2007/10/03)
Intermodular aminoacyl transfer is the fundamental bond-forming reaction in the biosynthesis of polypeptides by ribosomes and nonribosomal peptide synthetases (NRPS). Here we report the design and functional characterizations of short synthetic α-helical
Synthesis and Radioprotective Activity of New Cysteamine and Cystamine Derivatives
Oiry, J.,Pue, J. Y.,Imbach, J. L.,Fatome, M.,Sentenac-Roumanou, H.,Lion, C.
, p. 2217 - 2225 (2007/10/02)
A variety of N-(aminoalkanoyl)-S-acylcysteamine and N,N'-bis(aminoalkanoyl)cystamine salt derivatives were synthesized. Toxicity and radioprotective activity (as the dose reduction factor DRF) were determined in vivo on mice and compared to WR 2721 and S-acetylcysteamine hydrochloride. One of the most interesting compounds of this series was N-glycyl-S-acetylcysteamine trifluoroacetate (16, I 102). Structure-activity relationships are discussed.
