1040730-95-7Relevant academic research and scientific papers
Synthesis of dihydroquinoxaline-2(1H)-ones via palladium-catalyzed intramolecular C–N bond formation
Areephong, Jetsuda,Huo, Bright,Mbaezue, Ifenna I.,Ylijoki, Kai E.O.
, p. 3124 - 3126 (2016/07/06)
A new strategy for the preparation of highly-substituted dihydroquinoxaline-2(1H)-ones is reported. The strategy harnesses a divergent NaI-catalyzed amine substitution of mesylates to prepare a range of sterically hindered amidoamine substrates. These substrates are then subjected to Pd(dba)2/P(tBu)3mediated cyclization. The preparation of amidoalcohol substrates occurs with reasonable yields (40–84%), with lower yields being obtained with aromatic and bulky amines. Palladium-catalyzed intramolecular C–N bond formation is slow, requiring 10?mol?% catalyst loadings for complete conversion in 16?h. All substrates cyclized with reasonable yields (48–73%).
The preparation of 2H-1,4-benzoxazin-3-(4H)-ones via palladium-catalyzed intramolecular C-O bond formation
Ylijoki, Kai E. O.,Kuendig, E. Peter
supporting information; experimental part, p. 10608 - 10610 (2011/11/05)
Pd/PtBu3-catalyzed intramolecular C-O bond formation has been used to access aryl- and alkyl-substituted benzoxazinones.
