1040730-97-9Relevant academic research and scientific papers
Convenient synthesis of 3-alkoxy-3-aryloxindoles by intramolecular arylation of mandelic amides
Hillgren, J. Mikael,Marsden, Stephen P.
, p. 6459 - 6461 (2008/12/21)
(Chemical Equation Presented) Medicinally important 3-alkoxy-3- aryloxindoles are conveniently prepared by the rapid microwave-promoted palladium-catalyzed intramolecular enolate arylation of mandelate-derived anilides.
Chiral N-heterocyclic carbene ligands for asymmetric catalytic oxindole synthesis
Jia, Yi-Xia,Hillgren, J. Mikael,Watson, Emma L.,Marsden, Stephen P.,Kuendig, E. Peter
supporting information; scheme or table, p. 4040 - 4042 (2009/03/11)
The Pd-catalysed asymmetric intramolecular α-arylation of amide enolates containing heteroatom substituents gives chiral 3-alkoxy or 3-aminooxindoles in high yield and with enantioselectivities up to 97% ee when a new chiral N-heterocyclic carbene ligand is used. The Royal Society of Chemistry.
