104076-80-4

Basic information

• Product Name: Benzothiazole, 2-chloro-5,6-dimethyl- (9CI)
• Synonyms: Benzothiazole, 2-chloro-5,6-dimethyl- (9CI);Benzothiazole, 2-chloro-5,6-diMethyl-;2-Chloro-5,6-dimethyl-1,3-benzothiazole;2-Chloro-5,6-dimethylbenzo[d]thiazole, 97%
• CAS NO: 104076-80-4
• Molecular Formula: C9H8ClNS
• Molecular Weight: 197.68452
• Product Categories: BENZOTHIAZOLE
• Mol File: 104076-80-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzothiazole, 2-chloro-5,6-dimethyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzothiazole, 2-chloro-5,6-dimethyl- (9CI)(104076-80-4)
• EPA Substance Registry System: Benzothiazole, 2-chloro-5,6-dimethyl- (9CI)(104076-80-4)

Safety Data

• Hazardous Substances Data: 104076-80-4(Hazardous Substances Data)

Upstream product

• 29927-08-0 2-amino-5,6-dimethylbenzothiazole 

Relevant articles and documents

Synthesis and antibacterial evaluation of a novel series of 2-(1,2-dihydro-3-oxo-3H-pyrazol-2-yl)benzothiazoles

The 2-(1,2-dihydro-3-oxo-3H-pyrazol-2-yl)benzothiazole scaffold was selected as a central core structure for the discovery of novel antibacterial compounds. A systematic variation of the substituents on the oxo-pyrazole moiety, as well as on the benzo moiety, led to the creation of a small and focused library of benzothiazoles that was subjected to antibacterial screening. In a first round of screening, activity of the compounds against six representative microorganisms was established. For the most potent congeners, MIC values against S. aureus and P. aeruginosa were determined. The structure-activity relationship study clearly revealed that subtle structural variations influence the antibacterial activity to a large extent. The most potent congeners displayed MIC values of 3.30 μM.

BICYCLIC HETEROAROMATIC DERIVATIVES AS MODULATORS OF CXCR3 FUNCTION

A class of 1-substituted 4-(benzothiazol-2-ylamino) piperidine derivatives and related heterocyclic compounds, being potent and selective modulators of the interaction between CXCR3 and its chemokine ligands, are accordingly of use in the treatment and/or prevention of conditions involving inappropriate T-cell trafficking, including inflammatory, autoimmune and immunoregulatory disorders.

Histamine H2 -antagonist oxazole and thiazole derivatives and compositions therefor

This invention relates to aminoalkylphenoxyalkyl substituted heterocycles. These compounds antagonize the action of histamine on histamine H2 -receptors in the brain. A compound of the invention is 2-[3-[3-(piperidinomethyl)phenoxy]propylamino]benzthiazole.