10408-29-4

Basic information

• Product Name: (+-)-O-METHOXYMANDELIC ACID*DICYCLOHEXYL AMMONIUM
• Synonyms: (+-)-O-METHOXYMANDELIC ACID*DICYCLOHEXYL AMMONIUM;(2-methoxyphenyl)glycolic acid;(±)-o-Methoxymandelic acid (dicyclohexylammonium) salt;2-Methoxy-α-hydroxybenzeneacetic acid, DL-2-Methoxy-α-hydroxybenzeneacetic acid, (±)-o-Methoxymandelic acid dicyclohexylammonium salt;2-Methoxy-α-hydroxybenzeneacetic acid;o-Methoxymandelic acid;α-Hydroxy-2-methoxybenzeneacetic acid;2-hydroxy-2-(2-methoxyphenyl)acetic acid
• CAS NO: 10408-29-4
• Molecular Formula: C₉H₁₀O₄
• Molecular Weight: 182.1733
• EINECS: 233-878-0
• Mol File: 10408-29-4.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 375.3°Cat760mmHg
• Flash Point: 154.9°C
• Appearance: /
• Density: 1.309g/cm³
• Vapor Pressure: 2.68E-06mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: (+-)-O-METHOXYMANDELIC ACID*DICYCLOHEXYL AMMONIUM(CAS DataBase Reference)
• NIST Chemistry Reference: (+-)-O-METHOXYMANDELIC ACID*DICYCLOHEXYL AMMONIUM(10408-29-4)
• EPA Substance Registry System: (+-)-O-METHOXYMANDELIC ACID*DICYCLOHEXYL AMMONIUM(10408-29-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 10408-29-4(Hazardous Substances Data)

Usage

General Description

(+-)-O-METHOXYMANDELIC ACID is a chemical compound that belongs to the class of mandelic acids, which are aromatic alpha hydroxy acids. It is commonly used for its antibacterial and anti-inflammatory properties and has potential applications in the pharmaceutical industry for the treatment of various medical conditions. DICYCLOHEXYL AMMONIUM, on the other hand, is a quaternary ammonium compound with various industrial uses, including as a phase-transfer catalyst in organic synthesis. When combined, it is possible that these chemicals may have synergistic effects and could potentially be used in tandem for certain applications, such as drug development or organic synthesis.

InChI:InChI=1/C9H10O4/c1-13-7-5-3-2-4-6(7)8(10)9(11)12/h2-5,8,10H,1H3,(H,11,12)

Upstream product

• 75-25-2 Bromoform 
• 135-02-4 ortho-anisaldehyde 
• 26767-06-6 2-(2-methoxyphenyl)-2-oxoacetic acid 
• 579-74-8 2-Methoxyacetophenone 
• 67-66-3 chloroform 
• 121985-99-7 2-hydroxy-2-(2-methoxyphenyl)acetonitrile 

Downstream Products

• 21165-11-7 methyl (+/-)-α-hydroxy-α-(2-methoxyphenyl)acetate 
• 41024-43-5 ethyl α-hydroxy-α-(o-methoxyphenyl)acetate 
• 579-75-9 2-Methoxybenzoic acid 
• 135-02-4 ortho-anisaldehyde 
• 1476804-82-6 C₂₃H₁₈N₂O₃ 
• 26767-06-6 2-(2-methoxyphenyl)-2-oxoacetic acid 
• 1476803-99-2 C₂₃H₂₀N₂O₄ 
• 1965-19-1 2-(2-methoxyphenyl)-4,5-diphenyl-1H-imidazole 
• 1111730-44-9 2(S)-N-(3,4-dimethoxy-phenyl)-2-hydroxy-2-(2-methoxy-phenyl)-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-acetamide 
• 757877-58-0 6β-[(Ξ)-2-azido-2-(2-methoxy-phenyl)-acetylamino]-penicillanic acid 
• 3381-70-2 6β-[(Ξ)-2-amino-2-(2-methoxy-phenyl)-acetylamino]-penicillanic acid 
• 3609-39-0 azido-(2-methoxy-phenyl)-acetic acid 
• 99552-78-0 methyl 2-bromo-2-(2-methoxyphenyl)acetate 

Relevant articles and documents

Relationships between the racemic structures of substituted mandelic acids containing 8- and 10-membered hydrogen bonded dimer rings

The structures of 27 monosubstituted mandelic acids, including several of their polymorphs, plus unsubstituted mandelic acid itself (two polymorphs) are investigated for structural similarity. The results, presented pictorially as a structural relationship plot, show that rather more structures are built up from the carboxyl-chain hydroxyl hydrogen bonded dimer than from the conventional carboxylic acid dimer. The results show how all the structures are related and, based on the two types of dimer, the degree of similarity that they possess. Some structures with Z′ > 1 contain both sorts of dimers and there are many examples of isostructural sets within the structures so far determined. We also present an example where analysing similarity in related families of structures highlights a structure that should be present and which has indeed then proceeded to be synthesised and determined.

The preparation of various new heterocyclic compounds via cyclization of substituted derivatives of phenacyl esters of hydrazonoacetic acid

A procedure for the preparation of derivatives of phenacyl hydrazonopropanoates and their application in the synthesis of various heterocycles has been developed. Not only is the preparation of indole derivatives described, but also a new method for the preparation of previously unknown pyridazine derivatives.

CeCl3·7H2O: An effective additive in ru-catalyzed enantioselective hydrogenation of aromatic α-ketoesters

(Chemical Equation Presented) In the presence of catalytic amounts of CeCl3·7H2O, [RuCl(benzene)(S)-SunPhos]Cl is a highly effective catalyst for the asymmetric hydrogenation of aromatic α-ketoesters. A variety of ethyl α-hydroxy-α-arylacetates have been prepared in up to 98.3% ee with a TON up to 10 000. Challenging aromatic α-ketoesters with ortho substituents are also hydrogenated with high enantioselectivities. The addition of CeCl3·7H2O not only improves the enantioselectivity but also enhances the stability of the catalyst. The ratio of CeCl3·7H2O to [RuCl(benzene)(S)-SunPhos]Cl plays an important role in the hydrogenation reaction with a large substrate/catalyst ratio.