104091-11-4

Basic information

• Product Name: FMOC-D-GLU(OBZL)-OH
• Synonyms: N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-D-GLUTAMIC-ACID-GAMMA-BENZYL ESTER;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-GLUTAMIC ACID GAMMA-BENZYL ESTER;FMOC-D-GLU(BZL)-OH;FMOC-D-GLUTAMIC ACID GAMMA-BENZYL ESTER;FMOC-D-GLUTAMIC ACID(OBZL)-OH;FMOC-D-GLU(OBZL)-OH;Fmoc-D-glutamic acid γ-benzyl ester;N-ALPHA-(9-FLUOROENYLMETHYLOXYCARBONYL)-D-GLUTAMIC-ACID--BENZYL ESTER
• CAS NO: 104091-11-4
• Molecular Formula: C₂₇H₂₅NO₆
• Molecular Weight: 459.49
• Mol File: 104091-11-4.mol

Chemical Properties

• Boiling Point: 698.2±55.0 °C(Predicted)
• Appearance: /Solid
• Density: 1.289±0.06 g/cm3(Predicted)
• Storage Temp.: Store at RT.
• PKA: 3.70±0.10(Predicted)
• CAS DataBase Reference: FMOC-D-GLU(OBZL)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-D-GLU(OBZL)-OH(104091-11-4)
• EPA Substance Registry System: FMOC-D-GLU(OBZL)-OH(104091-11-4)

Safety Data

• Hazardous Substances Data: 104091-11-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
FMOC-D-GLU(OBZL)-OH is used as a building block in peptide synthesis for the development of therapeutic peptides with specific biological activities. Its protected structure ensures the stability and correct sequence of the synthesized peptides, which can be crucial for their efficacy and safety.
Used in Research and Development:
In the field of research, FMOC-D-GLU(OBZL)-OH is utilized as a component in the study of protein structure and function. Its protected nature allows for controlled synthesis and manipulation of peptides, facilitating the investigation of their interactions with other biomolecules and their role in various biological processes.
Used in Drug Discovery:
FMOC-D-GLU(OBZL)-OH is employed as a key component in drug discovery, where its incorporation into peptide-based drug candidates can lead to the development of novel therapeutic agents. Its protected structure ensures the integrity of the peptide during synthesis, potentially enhancing the drug's efficacy and reducing side effects.
Overall, FMOC-D-GLU(OBZL)-OH is a versatile compound with applications spanning across the pharmaceutical, research, and drug discovery industries, primarily due to its role in peptide synthesis and its protective properties that ensure the stability and functionality of the resulting peptides.

Upstream product

• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 2578-33-8 D-glutamic acid-5-benzyl ester 
• 104091-09-0 N-Fmoc-D-glutamic acid 
• 100-51-6 benzyl alcohol 

Relevant articles and documents

Identification of inhibitors of an 80 kDa protease from Trypanosoma cruzi through the screening of a combinatorial peptide library

Two orthogonal peptide combinatorial libraries were screened to discover inhibitors of Tc80 protease, a novel target from Trypanosoma cruzi involved in host cell invasion. These libraries were composed of 15625 structurally diversified tripeptides, partit

Synthesis of (R)- and (S)-(glu)Thz and the Corresponding Bisthiazole Dipeptide of Dolastatin 3

Dolastatin 3 (1) has been reported to be a cyclic pentapeptide containing two thiazole amino acids, (gly)Thz (2) and (gln)Thz (3).The syntheses of (R)- and (S)-(glu)Thz (8a,b) and (glu)Thz-(gly)Thz (11a,b) derivatives suitable for elaboration to dolastatin 3 are described.A key feature of the (glu)Thz syntheses is the selective thiation of a primary amide with Lawesson's reagent in the presence of ester and urethane functionalities.