1040912-41-1Relevant academic research and scientific papers
Selective nucleoside triphosphate diphosphohydrolase-2 (NTPDase2) inhibitors: Nucleotide mimetics derived from uridine-5′-carboxamide
Brunschweiger, Andreas,Iqbal, Jamshed,Umbach, Frank,Scheiff, Anja B.,Munkonda, Mercedes N.,Sévigny, Jean,Knowles, Aileen F.,Müller, Christa E.
experimental part, p. 4518 - 4528 (2009/07/11)
Ecto-nucleoside triphosphate diphosphohydrolases (E-NTPDases, subtypes 1, 2, 3, 8 of NTPDases) dephosphorylate nucleoside tri- and diphosphates to the corresponding di- and monophosphates. In the present study we synthesized adenine and uracil nucleotide
Ectonucleotidase inhibitors
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Page/Page column 10; 18, (2008/06/13)
Present invention provides ectonucleotidase (ecto-nucleotide triphosphate diphosphohydrolase, NTPDase) inhibitors represented by the following formula, namely nucleotide mimetics as selective NTPDase inhibitors. It also provides methods for preparations of said compounds. Furthermore provided are pharmaceutical and diagnostic compositions comprising said compounds, and the use of said compounds in a medicament for treating diseases associated with ectonucleotidase activity and/or P2 receptors.
