104094-31-7

Usage

Uses

Used in Pharmaceutical Industry:
(E)-Methyl-4-(3-bromophenyl)-2-oxobut-3-enoate is used as a versatile building block in the synthesis of pharmaceuticals for its potential pharmacological activity, such as anti-inflammatory and anti-tumor properties.
Used in Agrochemical Industry:
(E)-Methyl-4-(3-bromophenyl)-2-oxobut-3-enoate is used as a building block in the synthesis of agrochemicals, contributing to the development of biologically active compounds for agricultural applications.
Used in Organic Synthesis:
(E)-Methyl-4-(3-bromophenyl)-2-oxobut-3-enoate is used as a reagent in organic synthesis for the preparation of various heterocyclic compounds, expanding its utility in the creation of diverse chemical entities.

Upstream product

• 74-88-4 methyl iodide 
• 3132-99-8 m-bromobenzoic aldehyde 
• 67-56-1 methanol 
• 1267589-63-8 potassium (E)-4-(3-bromophenyl)-2-oxobut-3-enoate 

Downstream Products

• 1267588-59-9 (3R,4R)-methyl 4-(3-bromophenyl)-2-oxo-3-phenyl-3,4-dihydro-2H-pyran-6-carboxylate 
• 1309576-43-9 (4R,5S)-methyl 5-benzyl-5-(3-bromobenzamido)-4-(3-bromophenyl)-6-oxo-5,6-dihydro-4H-pyran-2-carboxylate 
• 1309576-44-0 (4R,5S)-methyl 5-benzyl-4-(3-bromophenyl)-5-(3-chlorobenzamido)-6-oxo-5,6-dihydro-4H-pyran-2-carboxylate 
• 1228393-39-2 trimethyl 2-(3-bromophenyl)-4-oxobutane-1,1,4-tricarboxylate 
• 1257520-17-4 (4R,4aS,7aS)-methyl 4-(3-bromophenyl)-4,4a,5,7a-tetrahydrocyclopenta[b]pyran-2-carboxylate 

Relevant academic research and scientific papers

Facile synthesis of substituted diaryl sulfones: Via a [3 + 3] benzannulation strategy

A base-mediated [3 + 3] benzannulation strategy for the conversion of 1,3-bis(sulfonyl)propenes and β,γ-unsaturated α-ketoesters to diaryl sulfones has been developed. This method provides facile, metal-free and efficient access to highly substituted diaryl sulfones in good to excellent yields. In addition, the sulfonyl group could be easily removed or converted to other functional groups via an organostannane intermediate.

4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVE OR SALTS THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present invention provides a 4,5-dihydro-1H-pyrazole derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, and a pharmaceutical composition comprising the same. The 4,5-dihydro-1H-pyrazole derivative or its pharmaceutically acceptable salt effectively increases the LXR transcriptional activity, and therefore can be usefully applied for preventing or treating a dysfunction in cholesterol metabolism, such as cholesterol gallstone, hyperlipidemia, or coronary atherosclerosis.

A New Strategy for Enantioselective Construction of Multisubstituted Five-Membered Oxygen Heterocycles via a Domino Michael/Hemiketalization Reaction

A new highly enantioselective domino Michael/hemiketalization reaction of α-hydroxyacetophenone with β,γ-unsaturated α-keto esters for the synthesis of 2,2,4,5-tetrasubstituted chiral tetrahydrofurans is reported. With 2 mol% intramolecular dinuclear zinc

Organocatalytic Functionalization of carboxylic acids: Isothiourea- catalyzed asymmetric intra- and intermolecular Michael addition-lactonizations

Tetramisole promotes the catalytic asymmetric intramolecular Michael addition-lactonization of a variety of enone acids, giving carbo- and heterocyclic products with high diastereo- and enantiocontrol (up to 99:1 dr, up to 99% ee) that are readily derivatized to afford functionalized indene and dihydrobenzofuran carboxylates. Chiral isothioureas also promote the catalytic asymmetric intermolecular Michael addition-lactonization of arylacetic acids and α-keto-β,γ-unsaturated esters, giving anti-dihydropyranones with high diastereo- and enantiocontrol (up to 98:2 dr, up to 99% ee).