10410-28-3Relevant academic research and scientific papers
Efficient synthesis of chiral benzofuryl β-amino alcohols via a catalytic asymmetric Henry reaction
Chen, Wei,Zhou, Zhao-Hui,Chen, Hong-Bin
supporting information, p. 1530 - 1536 (2017/02/15)
Chiral β-amino alcohol ligands were found effective for the copper(ii)-catalyzed asymmetric Henry reaction of benzofuran-2-carbaldehydes with nitromethane, which led to the formation of (S)-enriched benzofuryl β-nitro alcohols with satisfactory enantioselectivities (up to 98% ee). Using this catalytic protocol, bioactive (S)-benzofuryl β-amino alcohols could be conveniently prepared in short steps.
Preparation of highly functionalised benzofurans from ortho-hydroxyphenones and dichloroethylene: Applications and mechanistic investigations
Schevenels, Florian,Tinant, Bernard,Declercq, Jean-Paul,Markó, István E.
supporting information, p. 4335 - 4343 (2013/04/24)
Highly functionalised benzofurans have been prepared from ortho-hydroxyphenones and 1,1-dichloroethylene. The key intermediate, a chloromethylene furan, smoothly rearranged into the corresponding benzofuran carbaldehyde under acidic conditions. Some mechanistic investigations have been performed and several biologically active benzofurans have been synthesised. Copyright
Efficient and connective assembly of highly functionalized benzofurans using o-hydroxyphenones and dichloroethylene
Schevenels, Florian,Marko, Istvan E.
supporting information; experimental part, p. 1298 - 1301 (2012/05/31)
The preparation of highly functionalized benzofurans by a unique and connective transformation is reported. Base-catalyzed condensation of o-hydroxyphenones with 1,1-dichloroethylene generates the corresponding chloromethylene furans. These labile intermediates undergo a facile rearrangement into benzofuran carbaldehydes under mild acidic conditions.
