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10410-29-4

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10410-29-4 Usage

General Description

6-methoxy-3-methyl-1-benzofuran-2-carboxylic acid is a chemical compound that belongs to the benzofuran derivative class. It is a carboxylic acid with a molecular formula of C11H10O4 and a molecular weight of 210.198 g/mol. 6-methoxy-3-methyl-1-benzofuran-2-carboxylic acid is characterized by a benzofuran ring with a methoxy group at the 6th position and a methyl group at the 3rd position. It also contains a carboxylic acid group at the 2nd position of the benzofuran ring. The chemical may have potential applications in pharmaceutical and medicinal chemistry due to its structural features and properties. Additional research and study are needed to fully understand its potential uses and effects.

Check Digit Verification of cas no

The CAS Registry Mumber 10410-29-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,4,1 and 0 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 10410-29:
(7*1)+(6*0)+(5*4)+(4*1)+(3*0)+(2*2)+(1*9)=44
44 % 10 = 4
So 10410-29-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H10O4/c1-6-8-4-3-7(14-2)5-9(8)15-10(6)11(12)13/h3-5H,1-2H3,(H,12,13)

10410-29-4 Well-known Company Product Price

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  • Aldrich

  • (CBR00327)  6-Methoxy-3-methyl-1-benzofuran-2-carboxylic acid  AldrichCPR

  • 10410-29-4

  • CBR00327-1G

  • 2,255.76CNY

  • Detail

10410-29-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-Methoxy-3-methyl-1-benzofuran-2-carboxylic acid

1.2 Other means of identification

Product number -
Other names 6-methoxy-3-methyl-1-benzofuran-2-carboxylic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10410-29-4 SDS

10410-29-4Relevant articles and documents

Design and synthesis of novel 6-hydroxy-4-methoxy-3-methylbenzofuran-7-carboxamide derivatives as potent Mnks inhibitors by fragment-based drug design

Wang, Shuxiang,Li, Bo,Liu, Bo,Huang, Min,Li, Deyi,Guan, Lihong,Zang, Jie,Liu, Dan,Zhao, Linxiang

, p. 4602 - 4614 (2018)

A novel series of 6-hydroxy-4-methoxy-3-methylbenzofuran-7-carboxamide derivatives featured with various C-2 substituents were designed and synthesized as Mnks inhibitors through fragment-based drug design. Among them, 5b, 5i, 5o and 8k showed the best Mnk2 inhibitory activity with IC50 values of 1.45, 1.16, 3.55 and 0.27 μM, respectively. And these compounds inhibited the activity of Mnk1 at the same time. Furthermore, compounds 5o and 8k exhibited anti-proliferative effects to human leukemia cancer THP-1 and MOLM-13 cell lines and colon cancer HCT-116 cell line. Moreover, Western blot assay suggested that 8k could decrease the levels of p-eIF4E in a dose-dependent manner in HCT-116 cells. Docking studies demonstrated strong interactions between 8k and Mnk2. Therefore, this unique benzofuran scaffold demonstrated great potential to be further explored as potent Mnks inhibitors with improved potency.

Synthesis, pharmacological studies and molecular modeling of some tetracyclic 1,3-diazepinium chlorides

Grant, Julie-Ann A.,Bonnick, Tamicka,Gossell-Williams, Maxine,Clayton, Terry,Cook, James M.,Jackson, Yvette A.

, p. 909 - 921 (2010)

Seven new 1,3-diazepinium chlorides exhibiting some structural similarities to the 1,4-benzodiazepines were synthesized. In a Hippocratic screen using mice, three of these salts, 3-methoxy-6-oxo-7,13-dihydro-6H-benzofuro[2,3-e]pyrido[1,2-a][1,3]diazepin-12-ium chloride (8a), 3-methoxy-9-methyl-6-oxo-7,13-dihydro-6H-benzofuro[2,3-e]pyrido[1,2-a][1,3]diazepin-12-ium chloride (8c) and 3-methoxy-11-methyl-6-oxo-7,13-dihydro-6H-benzofuro[2,3-e]pyrido[1,2-a][1,3]diazepin-12-ium chloride (8e) were examined for their effect on the central nervous system, and their activities compared to that of diazepam. On their own, salts 8a, 8c and 8e solicited no sedative effects on the behaviour of the animals. However, they elicited significant effects in combination with diazepam on diazepam-induced activities such as decreased motor activity, ataxia and loss of righting reflex. Compounds 8a and 8c were fitted into the pharmacophore/receptor model developed by Cook et al. with interaction at the L1, H1 and A2 sites indicating that they are potential inverse agonists of the Bz receptor. The compounds displayed some affinity for the α1 isoform of the GABAA/BzR (LDi interaction) but are non-selective for α5 (no L2 interaction). Results of binding affinity studies showed that compound 8a is mildly selective for the α1 receptor although not very potent (Ki = 746.5 nM). The significant potentiation of diazepam-induced ataxia and decreased motor activity by compounds 8a and 8c in the Hippocratic screen may be associated with α1 selectivity.

Heterocycles from 2-aminopyridine and derivatives of 3-methylbenzofuran-2-carboxylic acid

Jackson, Yvette A.,Williams, Mark F.

, p. 787 - 794 (2007/10/03)

3-Bromomethyl-2-carboethoxy-5,6-dimethoxybenzofuran (3b) reacted with 2-aminopyridine to give not only the expected 2-carboethoxy-5,6-dimethoxy-3-benzofuranmethyl-2′-aminopyridinium bromide (4b), but also N-(2-carboethoxy-5,6-dimethoxy-3-benzofuranmethyl)-N-2-pyridyl-amine (5). Synthesis of 3-methoxy-6,7,12-trihydro-6-oxo-[1]benzofurano-[2,3-c]-1H-pyrido[1,2-a][1,3] diazepinium bromide (1 2) is also described.

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