1041010-15-4

Basic information

• Product Name: (2E)-2-{1-acetyl-1,10b-dihydro-2-hydroxy-2-phenyl-pyrrolo[2,1-a]isoquinolin-3(2H)-ylidene}-1-phenylethanone
• Synonyms: (2E)-2-{1-acetyl-1,10b-dihydro-2-hydroxy-2-phenyl-pyrrolo[2,1-a]isoquinolin-3(2H)-ylidene}-1-phenylethanone
• CAS NO: 1041010-15-4
• Molecular Weight: 421.496
• Mol File: 1041010-15-4.mol

Chemical Properties

• CAS DataBase Reference: (2E)-2-{1-acetyl-1,10b-dihydro-2-hydroxy-2-phenyl-pyrrolo[2,1-a]isoquinolin-3(2H)-ylidene}-1-phenylethanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-2-{1-acetyl-1,10b-dihydro-2-hydroxy-2-phenyl-pyrrolo[2,1-a]isoquinolin-3(2H)-ylidene}-1-phenylethanone(1041010-15-4)
• EPA Substance Registry System: (2E)-2-{1-acetyl-1,10b-dihydro-2-hydroxy-2-phenyl-pyrrolo[2,1-a]isoquinolin-3(2H)-ylidene}-1-phenylethanone(1041010-15-4)

Safety Data

• Hazardous Substances Data: 1041010-15-4(Hazardous Substances Data)

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 119-65-3 isoquinoline 
• 1087-09-8 1,4-diphenyl-but-2-yne-1,4-dione 

Relevant articles and documents

A one-pot synthesis of 1,2-dihydroisoquinoline derivatives from isoquinoline via a four-component reaction

A four-component reaction for the synthesis of 1,2-dihydroisoquinoline derivatives is described. The Huisgen 1,4-dipolar intermediate, which is produced from isoquinoline and an electron-deficient acetylene compound 1, reacts with H2O in the presence of diketene to produce 1,2-dihydroisoquinoline derivatives 2 (Scheme 1). In addition, reaction of isoquinoline, dibenzoylacetylene (= 1,4-diphenylbut-2-yne-1,4-dione), and diketene in the presence of H2O leads to pyrroloisoquinoline derivative 7. The structures of the compounds 2a-f and 7 were corroborated spectroscopically (IR, 1H- and 13C-NMR, EI-MS) and by elemental analyses. A plausible mechanism for the reaction is proposed (Schemes 2 and 3).