104102-91-2

Upstream product

• 110925-45-6 2-[4-(benzyloxy)-3-nitrophenyl]ethanol 
• 110925-46-7 Toluene-4-sulfonic acid 2-(4-benzyloxy-3-nitro-phenyl)-ethyl ester 
• 96886-46-3 4-(2-dipropylamino-ethyl)-phenol 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 142-84-7 di-n-propylamine 
• 103574-48-7 methyl 3-nitro-4-benzyloxyphenylacetate 
• 100-44-7 benzyl chloride 
• 61873-93-6 methyl (4-hydroxy-3-nitrophenyl)acetate 
• 96886-51-0 4-(benzyloxy)-3-nitro-N,N-di-n-propylphenethylamine 
• 96886-47-4 4-hydroxy-3-nitro-N,N-di-n-propylphenethylamine 
• 96886-44-1 N,N-di-n-propyl-4-methoxyphenylacetamide 
• 96886-45-2 4-methoxy-N,N-di-n-propylphenethylamine 

Downstream Products

• 96886-49-6 N-[2-Benzyloxy-5-(2-dipropylamino-ethyl)-phenyl]-methanesulfonamide 
• 110925-48-9 N-[2-Benzyloxy-5-(2-dipropylamino-ethyl)-phenyl]-acetamide 
• 104103-26-6 N-[2-benzyloxy-5-(2-dipropylaminoethyl)phenyl]formamide 
• 101566-36-3 3-acetamido-4-hydroxy-N,N-di-n-propylphenethylamine 
• 101566-34-1 3-formamido-4-hydroxy-N,N-n-dipropylphenethylamine 
• 101566-37-4 3-acetamido-4-hydroxy-N,N-di-n-propylphenethylamine hydrochloride 
• 103544-39-4 2-benzyloxy-5-(2-N,N-di-n-propylaminoethyl)ureidobenzene 

Relevant academic research and scientific papers

Syntheses and in Vitro Evaluation of 4-(2-Aminoethyl)-2(3H)-indolones and Related Compounds as Peripheral Prejunctional Dopamine Receptor Agonists

A series of (β-aminoethyl)indolones and related compounds was synthesized and evaluated in vitro as peripheral prejunctional dopaminergic agonists in the field-stimulated isolated perfused rabbit ear artery. 4--7-hydroxy-2(3H)-indolone (26) was the most potent compound (ED50 = 2 +/- 0.3 nM) tested, while the related secondary amine 24 and the des-OH derivatives 28 and 34 were only slightly less potent. 4-Methoxy-benzeneethanamine and 2-methyl-3-nitrophenylacetic acid were employed as starting materials for the synthesis of the 4-(β-aminoethyl)indolones.The ring-opened 3-acylamino analogues 46 and 47 were prepared via nitration of the phenethylamine 43 derived from 4-methoxyphenylacetic acid.The inactive isomeric indolones 38, 39, and 41 were derived from 4-nitrobenzeneethanamine and from indolone-6-acetic acid (13).