1041193-41-2Relevant academic research and scientific papers
Click chemistry inspired synthesis of piperazine-triazole derivatives and evaluation of their antimicrobial activities
Khedar, Poonam,Pericherla, Kasiviswanadharaju,Singh, Rajnish Prakash,Jha, Prabhat Nath,Kumar, Anil
, p. 3117 - 3126 (2015)
A series of novel piperazine-1,2,3-triazole derivatives, which entailed the bioisosteric replacement of the imidazole moiety and hybridization of two drug scaffolds was prepared by employing the regioselective copper (I)-catalysed azide-alkyne 1,3-dipolar cycloaddition reaction. The synthesized compounds were evaluated for antibacterial activities against Gram-negative (E. Coli and P. Putida), Gram-positive S. Aureus bacteria and fungicidal activities against F. oxysporum, F. gramillarium and F. monalliforme fungi. Compound 7ac′ exhibited moderate but promising antibacterial activity against Gram-negative bacteria and fungicidal activity against F. oxysporum and F. gramillarium.
