1041198-49-5

Upstream product

• 108-24-7 acetic anhydride 
• 90390-46-8 (3-amino-5-nitrophenyl)methanol 
• 71022-43-0 3,5-dinitrobenzyl alcohol 

Downstream Products

• 1018448-89-9 3-acetamido-5-nitrobenzyl alcohol 
• 1018449-04-1 C₂₂H₃₀N₂O₃Si 
• 1018449-15-4 C₁₆H₁₆N₂O₃ 
• 1357620-17-7 N-(3-acetamido-5-((tert-butyldimethylsilyloxy)methyl)phenyl)-N'-(3-(dimethylamino)propyl) terephthalamide 
• 1357620-18-8 N-(3-acetamido-5-(hydroxymethyl)phenyl)-N'-(3-(dimethylamino)propyl)-terephthalamide 
• 1018449-03-0 C₁₅H₂₆N₂O₂Si 

Relevant academic research and scientific papers

Synthesis and biological activity of benzamide DNA minor groove binders

A range of di- and triaryl benzamides were synthesised to investigate the effect of the presence and nature of a polar sidechain, bonding and substitution patterns and functionalisation of benzylic substituents. These compounds were tested for their antiproliferative activity as well as their DNA binding activity. The most active compounds in all assays were unsymmetrical triaryl benzamides with a bulky or alkylating benzylic substituent and a polar amino sidechain.

Synthesis of non-symmetrical 3,5-diamidobenzyl amines, ethers and sulfides

A straightforward synthesis of non-symmetrical 3,5-diamidobenzyl amines, ethers and sulfides starting from 3,5-dinitrobenzoic acid is reported. Functionalization of the benzylic position is only achieved after formation of the two amides, otherwise benzylic hydrogenolysis occurs during nitro group reduction.