1041262-67-2Relevant academic research and scientific papers
Development of a concise synthesis of (-)-oseltamivir (Tamiflu)
Trost, Barry M.,Zhang, Ting
, p. 3630 - 3643 (2011/05/12)
We report a full account of our work towards the development of an eight-step synthesis of anti-influenza drug (-)-oseltamivir (Tamiflu) from commercially available starting materials. The final synthetic route proceeds with an overall yield of 30 %. Key transformations include a novel palladium-catalyzed asymmetric allylic alkylation reaction (Pd-AAA) as well as a rhodium-catalyzed chemo-, regio-, and stereoselective aziridination reaction.
A concise synthesis of (-)-oseltamivir
Trost, Barry M.,Zhang, Ting
, p. 3759 - 3761 (2008/12/23)
(Chemical Equation Presented) Tackling the supply problem: A short and efficient synthesis of (-)-oseltamivir has been developed which requires eight steps from commercially available starting materialand proceeds with an overall yield of 30%. Key transformations include a novel palladium-catalyzed asymmetric allylic alkylation reaction (Pd-AAA, see scheme) as well as a chemo-, regio-, and stereoselective aziridination reaction. Phth=phthaloyl.
