1041262-68-3

Basic information

• Product Name: (3R,4R,5S)-4-acetamido-5-(1,3-dioxoisoindol-2-yl)-3-(pentyl-3-yloxy)cyclohexyl-ethyl-1-ene-1-carboxylate
• Synonyms: (3R,4R,5S)-4-acetamido-5-(1,3-dioxoisoindol-2-yl)-3-(pentyl-3-yloxy)cyclohexyl-ethyl-1-ene-1-carboxylate
• CAS NO: 1041262-68-3
• Molecular Weight: 442.512
• Mol File: 1041262-68-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (3R,4R,5S)-4-acetamido-5-(1,3-dioxoisoindol-2-yl)-3-(pentyl-3-yloxy)cyclohexyl-ethyl-1-ene-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4R,5S)-4-acetamido-5-(1,3-dioxoisoindol-2-yl)-3-(pentyl-3-yloxy)cyclohexyl-ethyl-1-ene-1-carboxylate(1041262-68-3)
• EPA Substance Registry System: (3R,4R,5S)-4-acetamido-5-(1,3-dioxoisoindol-2-yl)-3-(pentyl-3-yloxy)cyclohexyl-ethyl-1-ene-1-carboxylate(1041262-68-3)

Safety Data

• Hazardous Substances Data: 1041262-68-3(Hazardous Substances Data)

Upstream product

• 4720-83-6 6-oxabicyclo<3.2.1>-oct-3-en-7-one 
• 584-02-1 2-pentanol 
• 10416-67-8 N-(trimethylsilyl)phthalimide 
• 1041262-63-8 ethyl (5S)-5-(1,3-dioxoisoindolin-2-yl)-1-(phenylthio)cyclohex-3-enecarboxylate 
• 1041262-62-7 ethyl (1S,5S)-5-(1,3-dioxoisoindolin-2-yl)cyclohex-3-enecarboxylate 
• 1041262-69-4 (3R,4R,5S)-ethyl 5-(1,3-dioxoisoindolin-2-yl)-3-hydroxy-4-(2-(trimethylsilyl)ethylsulfonamido)cyclohex-1-enecarboxylate 
• 1041262-66-1 ethyl (3R,4R,5S)-5-(1,3-dioxoisoindolin-2-yl)-3-(pentan-3-yloxy)-4-[2-(trimethylsilyl)ethylsulfonamido]cyclohex-1-enecarboxylate 
• 1041262-67-2 ethyl (3R,4R,5S)-5-(1,3-dioxoisoindolin-2-yl)-3-(pentan-3-yloxy)-4-{N-[2-(trimethylsilyl)ethylsulfonyl]acetamido}cyclohex-1-enecarboxylate 
• 949908-55-8 pentan-3-yl 2,2,2-trichloroacetimidate 
• 75-36-5 acetyl chloride 
• 1238305-33-3 (E)-2-(2-nitrovinyl)isoindoline-1,3-dione 

Downstream Products

• 196618-13-0 oseltamivir 

Relevant articles and documents

Synthesis method of oseltamivir phosphate

The invention belongs to the technical field of oseltamivir phosphate, and particularly relates to a synthesis method of oseltamivir phosphate. The synthesis method of oseltamivir phosphate comprises the following steps: step 1, carrying out acetylation reaction on a compound as shown in a formula IV to obtain a compound as shown in a formula V; step 2, removing tertiary butyl from the compound as shown in the formula V to obtain a compound as shown in a formula VI; and step 3, removing a phthaloyl protecting group from the compound as shown in the formula VI, and then carrying out salt-forming reaction on the obtained product and phosphoric acid to obtain oseltamivir phosphate as shown in the formula I. The invention provides the synthesis method of oseltamivir phosphate, and provides the industrial synthesis method of oseltamivir phosphate, wherein the method does not need an expensive metal catalyst, has high yield, is convenient to operate and does not have heavy metal residues.

Development of a concise synthesis of (-)-oseltamivir (Tamiflu)

We report a full account of our work towards the development of an eight-step synthesis of anti-influenza drug (-)-oseltamivir (Tamiflu) from commercially available starting materials. The final synthetic route proceeds with an overall yield of 30 %. Key transformations include a novel palladium-catalyzed asymmetric allylic alkylation reaction (Pd-AAA) as well as a rhodium-catalyzed chemo-, regio-, and stereoselective aziridination reaction.