104131-92-2

Upstream product

• 1346641-17-5 C₁₁H₂₀O₂ 
• 104131-90-0 1-(1-Methylethenyl)cyclopropancarbonsaeure-ethylester 
• 32933-03-2 ethyl 1-acetylcyclopropanecarboxylate 
• 104131-91-1 1-(1-Methylethyl)cyclopropancarbonsaeure-ethylester 

Downstream Products

• 1448600-52-9 C₁₃H₁₈BrN 
• 1448600-33-6 C₁₃H₁₆BrNO 
• 1448599-99-2 N-(2-bromophenyl)-1,1,1-trifluoro-N-((1-isopropylcyclopropyl)methyl)methanesulfonamide 
• 1346641-03-9 N-(4-cyano-2,3,5,6-tetrafluorophenyl)-1-isopropylcyclopropanecarboxamide 

Relevant academic research and scientific papers

Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes

Systematic ligand development has led to the identification of novel mono-N-protected amino acid ligands for Pd(II)-catalyzed enantioselective C-H activation of cyclopropanes. A diverse range of organoboron reagents can be used as coupling partners, and the reaction proceeds under mild conditions. These results provide a new retrosynthetic disconnection for the construction of enantioenriched cis-substituted cyclopropanecarboxylic acids.

Deamination Reactions, 44. Decomposition of 1-Alkylcyclopropanediazonium Ions

1-Methyl- (17), 1,2-dimethyl- (41, 44), 1-propyl- (64), 1-(1-methylethyl)cyclopropanediazonium ions (80), and -1-diazonium ions (93) have been generated by alkaline cleavage of the analogous nitrosocarbamates in methanol.Cyclopropyl-allyl transformation and nucleophilic displacement were the only reactions of 17, 41, 44, and 93 while elimination and 1,2-shifts of an α-hydrogen compete increasingly with 64 and 80.The stereochemistry of ring cleavage and nucleophilic displacement has been explored, using 2-D labels in the case of 17 and 93.Cyclopropanediazonium ions (1) and 41 react stereospecifically, 17 and 44 are moderately stereoselective (ca. 85:15), and 93 is entirely unselective.The data indicate a gradual changeover from concerted to stepwise mechanisms.Appreciable stabilization of the positive charge is required to reach the SN1 extreme.