32933-03-2Relevant articles and documents
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Batty et al.
, p. 534 (1971)
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AMINO ESTER DERIVATIVES, SALTS THEREOF AND METHODS OF USE
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Paragraph 0368, (2016/08/17)
The present invention provides amino ester compounds, salts, and pharmaceutical formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.
Preparation method for efficiently synthesizing Sitafloxacin midbody (7S)-5-azaspiro[2.4] heptanes-7-phenylbutane
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Paragraph 0048; 0049, (2017/02/17)
The invention discloses a preparation method for efficiently synthesizing Sitafloxacin midbody (7S)-5-azaspiro[2.4] heptanes-7-phenylbutane. The method comprises the following steps that a first material shown as the accompanying drawing takes a reaction to obtain a second material shown as the accompanying drawing; the second material takes a reaction to obtain a third material shown as the accompanying drawing; the third material takes a reaction to obtain a fourth material shown as the accompanying drawing; the fourth material takes a reaction to obtain a fifth material shown as the accompanying drawing. The preparation method has the advantages that the single compound with a high ee value can be obtained; the unnecessary waste of materials is avoided; the yield is obviously improved; the operation is simple; the industrial application is easy; the production cost is reduced.