32933-03-2

Usage

Uses

Used in Flavoring Industry:
Ethyl 1-acetylcyclopropanecarboxylate is utilized as a flavoring agent in the food industry, where its fruity aroma enhances the sensory experience of various food products.
Used in Pharmaceutical Synthesis:
In the pharmaceutical sector, ethyl 1-acetylcyclopropanecarboxylate serves as a key intermediate in the synthesis of a range of pharmaceuticals, contributing to the development of new medications.
Used in Agricultural Chemicals:
ethyl 1-acetylcyclopropanecarboxylate is also employed in the production of agricultural chemicals, where it plays a role in the synthesis of substances that aid in crop protection and enhancement of agricultural yields.

InChI:InChI=1/C8H12O3/c1-3-11-7(10)8(4-5-8)6(2)9/h3-5H2,1-2H3

Upstream product

• 106447-93-2 2-(2-bromo-ethyl)-acetoacetic acid ethyl ester 
• 141-52-6 sodium ethanolate 
• 141-97-9 ethyl acetoacetate 
• 106-93-4 ethylene dibromide 
• 6307-04-6 dimethyl-(2-phenoxy-ethyl)-sulfonium; iodide 
• 14668-82-7 vinyl isocyanide 
• 64648-13-1 S-ethenyl-S-(4-methylphenyl)-N-tosylsulfilimine 
• 56692-06-9 S-ethenyl-S-phenyl-N-(toluene-4-sulfonyl)sulfilimine 
• 75-03-6 ethyl iodide 
• 247129-85-7 (2-bromoethyl)(diphenyl)sulfonium trifluoromethanesulfonate 
• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 107-06-2 1,2-dichloro-ethane 

Downstream Products

• 99159-15-6 1-acetylcyclopropane-1-carboxamide 
• 7721-57-5 7-methyl-5,6-diazaspiro[2.4]hept-6-en-4-one 
• 87268-46-0 3-Ethoxy-5-methyl-4-(2-chloroethyl)pyrazole Hydrochloride 
• 3884-71-7 bromo-5-pentanone-2 
• 56172-71-5 1-Acetylcyclopropane-1-carboxylic acid 
• 412295-21-7 N-[(1-ethoxycarbonylcycloprop-1-yl)carbonylmethyl]-N-[(S)-1-phenylethyl]-2-(diethoxyphosphoryl)-2-fluoroacetamide 
• 129306-04-3 5-benzyl-5-azaspiro[2.4]heptane-4,7-dione 
• 1221443-13-5 N'-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide 
• 1221442-95-0 N-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide 
• 1221443-01-1 N'-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-N-phenylcyclopropane-1,1-dicarboxamide 
• 1221442-96-1 N-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)quinolin-4-yloxy)-3-fluorophenyl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide 
• 1221442-98-3 N-(5-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)pyridin-2-yl)-2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide 
• 1221442-99-4 N'-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)quinolin-4-yloxy)-3-fluorophenyl)-N-phenylcyclopropane-1,1-dicarboxamide 
• 1221443-14-6 N'-(5-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)-6-methoxyquinolin-4-yloxy)pyridin-2-yl)-N-phenylcyclopropane-1,1-dicarboxamide 

Relevant academic research and scientific papers

Having a spiro ring substituent of aryl morpholine compound, its preparation and use

The invention discloses arylmorpholine compounds with spiro substituents. The arylmorpholine compounds are compounds having the following general formula (I), wherein X is N or CH; R1 is hydrogen, hydroxyl, alkoxy, halogen, amino, amido, acylamino, sulfam

An efficient method for the synthesis of 2′,3′-nonsubstituted cycloalkane-1,3-dione-2-spirocyclopropanes using (2-bromoethyl)-diphenylsulfonium trifluoromethanesulfonate

An efficient and practical synthesis of 2′,3′-nonsubstituted cyclohexane-1,3-dione-2-spirocyclopropanes using a sulfonium salt was achieved. The reaction of 1,3-cyclohexanediones and (2-bromoethyl)diphenylsulfonium trifluoromethanesulfonate with powdered K2CO3 in EtOAc at room temperature (r.t.) provided the corresponding spirocyclopropanes in high yields. The synthetic method was also applied to 1,3-cyclopentanedione, 1,3-cycloheptanedione, 1,3-indanedione, acyclic 1,3-diones, ethyl acetoacetate, and Meldrum's acid.

AMINO ESTER DERIVATIVES, SALTS THEREOF AND METHODS OF USE

The present invention provides amino ester compounds, salts, and pharmaceutical formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

Hydroxypurine compound and use thereof

The invention discloses a hydroxypurine compound and a use of the hydroxypurine compound as a PDE2 or TNFa inhibitor and concretely discloses a compound shown in the formula (I) and its tautomer or pharmaceutically acceptable salt.

Preparation method for efficiently synthesizing Sitafloxacin midbody (7S)-5-azaspiro[2.4] heptanes-7-phenylbutane

The invention discloses a preparation method for efficiently synthesizing Sitafloxacin midbody (7S)-5-azaspiro[2.4] heptanes-7-phenylbutane. The method comprises the following steps that a first material shown as the accompanying drawing takes a reaction to obtain a second material shown as the accompanying drawing; the second material takes a reaction to obtain a third material shown as the accompanying drawing; the third material takes a reaction to obtain a fourth material shown as the accompanying drawing; the fourth material takes a reaction to obtain a fifth material shown as the accompanying drawing. The preparation method has the advantages that the single compound with a high ee value can be obtained; the unnecessary waste of materials is avoided; the yield is obviously improved; the operation is simple; the industrial application is easy; the production cost is reduced.

COMBINATIONS OF HEPATITIS C VIRUS INHIBITORS

The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such combinations, and methods for inhibiting the function of the NS5A protein.

Synthesis of (S)-7-amino-5-azaspiro[2.4]heptane via highly enantioselective hydrogenation of protected ethyl 1-(2-aminoaceto)cyclopropanecarboxylates

Highly effective asymmetric hydrogenation of protected ethyl 1-(2-aminoaceto)cyclopropane carboxylates in the presence of [RuCl(benzene)(S)-SunPhos]Cl was realized, and high enantioselectivities (up to 98.7% ee) were obtained. This asymmetric hydrogenation provides a key intermediate for the enantioselective synthesis of (S)-7-amino-5-azaspiro[2.4] heptane moiety of quinolone antibacterial agents.

Synthesis of enantiomerically enriched α,α-disubstituted β,γ-epoxy esters using hydrolytic kinetic resolution catalyzed by salenCo(III)

Novel α,α-disubstituted epoxy esters were prepared in enantiopure form by hydrolytic kinetic resolution (HKR) of the corresponding racemic mixtures using chiral salenCo(III) as catalyst. The methodology provides a convenient route to enantioenriched β,γ-epoxy esters 2a, 2c and 2d.

AMINO ESTER DERIVATIVES, SAILTS THEREOF AND METHODS OF USE

The present invention provides amino ester compounds, salts, and pharmaceutical formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

COMPOUNDS AND METHODS OF USE

The present invention provides novel compounds useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.