1041425-06-2Relevant academic research and scientific papers
An expeditious and atom-economic synthesis of lead-like, medicinally important 4,5-dihydropyrazolo[1,5-a]pyrazin-6-ones
Mujumdar, Prashant,Sapegin, Alexander,Dorogov, Mikhail,Krasavin, Mikhail
, p. 5732 - 5735 (2014)
We have developed an expeditious and atom-economic synthesis of lead-like, privileged 4,5-dihydropyrazolo[1,5-a]pyrazin-6-ones, which is based on Sonogashira coupling and a two-step condensation with hydrazine hydrate leading to two ring-forming events, with full control over the two elements of diversity present.
Facile entry to 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]pyrazin-6-ones from amines and amino acids
Sai Sudhir,Nasir Baig,Chandrasekaran, Srinivasan
experimental part, p. 2423 - 2429 (2009/04/06)
A practical and high-yielding regioselective synthesis of several enantiopure 4,5,6,7-tetrahydro[1,2,3]triazolo[1,5-a]-pyrazin-6-ones is described starting from primary amines and α-amino acid derivatives in a three-step reaction sequence by employing a constrained intramolecular "click" reaction as the key step. The method obviates chromatographic purification of products. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
