104155-89-7 Usage
Chemical compound
10,11-methylenedioxy-20-camptothecin is a chemical compound that has shown promising anti-cancer properties in preclinical studies.
Semi-synthetic derivative
It is a semi-synthetic derivative of camptothecin, a natural product isolated from the Chinese tree Camptotheca acuminata.
Inhibits topoisomerase I
10,11-methylenedioxy-20-camptothecin has been found to inhibit the activity of topoisomerase I, an enzyme involved in DNA replication and cell division.
Inhibition of cancer cell growth
By inhibiting topoisomerase I, 10,11-methylenedioxy-20-camptothecin leads to the inhibition of cancer cell growth.
Potential in multidrug-resistant cancers
Research has suggested that 10,11-methylenedioxy-20-camptothecin may have potential in the treatment of multidrug-resistant cancers.
Combination therapies
10,11-methylenedioxy-20-camptothecin may also have potential in combination therapies with other anti-cancer drugs.
More studies needed
More studies are needed to fully understand its safety and efficacy in humans before it can be used as a clinical treatment for cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 104155-89-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,1,5 and 5 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 104155-89:
(8*1)+(7*0)+(6*4)+(5*1)+(4*5)+(3*5)+(2*8)+(1*9)=97
97 % 10 = 7
So 104155-89-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H16N2O6/c1-2-21(26)13-5-15-18-11(7-23(15)19(24)12(13)8-27-20(21)25)3-10-4-16-17(29-9-28-16)6-14(10)22-18/h3-6,26H,2,7-9H2,1H3/t21-/m0/s1
104155-89-7Relevant academic research and scientific papers
7-Substituted camptothecin and camptothecin analogs and methods for producing the same
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Page 4, (2008/06/13)
Methods of forming camptothecin compounds which are effective anti-tumor compounds are disclosed. These compounds inhibit the enzyme topoisomerase I and may alkylate DNA of the associated topoisomerase I-DNA cleavable complex.
