1041611-84-0

Basic information

• Product Name: 3-[(R)-3-t-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)-butyryl]-thiazolidine-2-carboxylic acid
• Synonyms: 3-[(R)-3-t-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)-butyryl]-thiazolidine-2-carboxylic acid
• CAS NO: 1041611-84-0
• Molecular Weight: 448.463
• Mol File: 1041611-84-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-[(R)-3-t-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)-butyryl]-thiazolidine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(R)-3-t-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)-butyryl]-thiazolidine-2-carboxylic acid(1041611-84-0)
• EPA Substance Registry System: 3-[(R)-3-t-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)-butyryl]-thiazolidine-2-carboxylic acid(1041611-84-0)

Safety Data

• Hazardous Substances Data: 1041611-84-0(Hazardous Substances Data)

Upstream product

• 1041611-83-9 methyl 3-[(R)-3-t-butoxycarbonylamino-4-(2,4,5-trifluorophenyl)-butyryl]-thiazolidine-2-carboxylate 
• 486460-00-8 (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid 
• 1283679-05-9 C₂₁H₂₇F₃N₂O₅S 

Downstream Products

• 1041611-95-3 ethyl 1-(3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carbonyl)piperidine-4-carboxylate 
• 1041611-85-1 tert-butyl (2R)-4-(2-(benzylcarbamoyl)thiazolidin-3-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate 
• 1041611-89-5 ethyl 2-(4-(3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)phenoxy)acetate 
• 1041612-07-0 tert-butyl (2R)-4-(2-(2-(1H-imidazol-4-yl)ethylcarbamoyl)thiazolidin-3-yl)-4-oxo-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate 
• 1041611-87-3 ethyl 2-(4-((3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)-phenoxy)acetate 
• 1041611-91-9 ethyl 2-(4-((3-((R)-3-(t-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)phenoxy)-3-methylbutanoate 
• 1041611-97-5 ethyl 2-(4-((3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)phenyl)acetate 
• 1041611-99-7 ethyl 2-(2-(3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carbonyl)-1,2,3,4-tetrahydroisoquinolin-7-yloxy)-3-methylbutanoate 
• 1041612-02-5 ethyl 6-((3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxylate 
• 1041612-28-5 (S)-ethyl 2-(4-(((S)-3-((R)-3-(tert-butoxycarbonylamino)-4-(2,4,5-trifluorophenyl)butanoyl)thiazolidine-2-carboxamido)methyl)phenylamino)-3-methylbutanoate 
• 1041612-06-9 C₂₃H₃₀F₃N₃O₅S 
• 1283678-66-9 C₂₀H₂₁F₃N₄O₂S*ClH 
• 1041609-97-5 3-((R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl)-N-(4-hydroxybenzyl)thiazolidine-2-carboxamide hydrochloride 
• 1041610-13-2 C₂₂H₂₂F₃N₃O₄S*ClH 

Relevant articles and documents

Discovery of β-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors

A series of β-aminoacyl containing thiazolidine derivatives was synthesized and evaluated for their ability to inhibit DPP-IV. Several thiazolidine derivatives with an acid moiety were found to be potent DPP-IV inhibitors. Among them, compound 2da is the most active in this series with an IC50 value of 1 nM, and it showed excellent selectivity over DPP-IV related enzymes including DPP-2, DPP-8, and DPP-9. Compound 2da is chemically and metabolically stable, and showed no CYP inhibition, hERG binding or cytotoxicity. Compound 2db, an ester prodrug of 2da, showed good in vivo DPP-IV inhibition after oral administration in rat and dog models.