1041643-93-9

Basic information

• Product Name: C₁₄H₁₈N₂O₅
• CAS NO: 1041643-93-9
• Molecular Weight: 294.307
• Mol File: 1041643-93-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₄H₁₈N₂O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₄H₁₈N₂O₅(1041643-93-9)
• EPA Substance Registry System: C₁₄H₁₈N₂O₅(1041643-93-9)

Safety Data

• Hazardous Substances Data: 1041643-93-9(Hazardous Substances Data)

Upstream product

• 93270-42-9 Ethyl 3,4,5-Trimethoxyphenylacetimidate Hydrochloride 
• 1482-97-9 (S)-2,3-diaminopropanoic acid hydrochloride 

Downstream Products

• 1041643-68-8 C₃₀H₅₁N₃O₄ 

Relevant articles and documents

Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma

We have previously reported substituted 2-aryl-thiazolidine-4-carboxylic acid amides as potent and selective antiproliferative agents for melanoma. To understand the importance of the thiazolidine ring and to reduce potential complications associated with the two chiral centers, we designed and synthesized sets of new analogs by modifying this ring. These new analogs were tested in two melanoma cell lines and fibroblast cells (negative controls). Compared with the older analogs containing the thiazolidine ring, these new analogs have lower potency in general, but some of these analogs still have very good selectivity. These structure-activity studies indicated that the thiazolidine ring is very critical for the activity for these series of compounds.