1041672-46-1

Basic information

• Product Name: 1,3,5-Triazin-2(1H)-one, 4-amino-1-(3,5-di-O-acetyl-2-deoxy-a-D-erythro-pentofuranosyl)-
• CAS NO: 1041672-46-1
• Molecular Formula: C₁₂H₁₆N₄O₆
• Molecular Weight: 312.28224
• Mol File: 1041672-46-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,3,5-Triazin-2(1H)-one, 4-amino-1-(3,5-di-O-acetyl-2-deoxy-a-D-erythro-pentofuranosyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,5-Triazin-2(1H)-one, 4-amino-1-(3,5-di-O-acetyl-2-deoxy-a-D-erythro-pentofuranosyl)-(1041672-46-1)
• EPA Substance Registry System: 1,3,5-Triazin-2(1H)-one, 4-amino-1-(3,5-di-O-acetyl-2-deoxy-a-D-erythro-pentofuranosyl)-(1041672-46-1)

Safety Data

• Hazardous Substances Data: 1041672-46-1(Hazardous Substances Data)

Usage

General Description

1,3,5-Triazin-2(1H)-one, 4-amino-1-(3,5-di-O-acetyl-2-deoxy-a-D-erythro-pentofuranosyl)- is a chemical compound with a triazinone ring and an aminopentofuranosyl moiety. It is commonly used in the pharmaceutical industry as an intermediate for the synthesis of nucleoside analogues, which have potential antiviral and anticancer properties. The compound contains a 1,3,5-triazin-2-one core and a 4-amino-1-(3,5-di-O-acetyl-2-deoxy-a-D-erythro-pentofuranosyl) side chain, making it a valuable building block for the development of novel drugs and therapeutics. Further research and studies are being conducted to explore the potential biological and pharmacological activities of this compound.

Upstream product

• 52523-35-0 2-(trimethylsilylamino)-4-(trimethylsilyloxy)-s-triazine 
• 151767-35-0 3,5-di-O-acetyl-2-deoxy-α/β-D-ribofuranoside 
• 4594-52-9 1,3,5-tri-O-acetyl-2-deoxyribose 

Downstream Products

• 2353-33-5 5-aza-2'-deoxycytidine 

Relevant articles and documents

Synthesis and properties of cross-linkable DNA duplex using 4-amino-2-oxo-6-vinyl-1,3,5-triazine

We synthesized the DNA oligonucleotide containing a new cross-linkable 4-amino-2-oxo-6-vinyltriazine (AOVT) nucleobase analogue (Et-AOVT) and evaluated these properties. Our results of the cross-link assay and thermal denaturing assay of duplexes containing AOVT demonstrated that the additional aza of AOVT has an impact on the duplex stability and crosslink properties. Our data suggests that the additional 5-aza of AOVT is involved in the hydrogen bonding with the complementary guanine, and this hydrogen bonding system successfully flipped the reactive vinyl group out to the major groove of the duplex demonstrating a new paradigm of a “cross-linkable duplex”.

Method for synthesizing decitabine intermediate

The invention relates to a method for synthesizing a decitabine intermediate, in particular to a method for synthesizing the decitabine intermediate with a structure shown in a formula 2. According tothe method, the purity of the intermediate can be greatly improved, so that the purification operation of decitabine is reduced, a transition state intermediate compound is successfully separated forthe first time, and the total yield of decitabine is increased by three times.