104170-15-2

Upstream product

• 1121-60-4 pyridine-2-carbaldehyde 
• 189440-33-3 (2-aminoethyl)bis(2-pyridylmethyl)amine 

Downstream Products

• 1419074-86-4 [(N-(1-(4-methoxy-phenyl)-1H-[1,2,3]triazol-4-ylmethyl)-N,N′,N′-tris(pyridin-2-ylmethyl)-ethane-1,2-diamine)FeCl]PF₆ 
• 1419075-10-7 N-(1-(4-methoxy-phenyl)-1H-[1,2,3]triazol-4-ylmethyl)-N,N′,N′-tris(pyridin-2-ylmethyl)-ethane-1,2-diamine 
• 1111625-98-9 NBD-TPEA 

Relevant academic research and scientific papers

Water-soluble tetrapodal N,O ligands incorporating soft N-heterocycles for the selective complexation of Am(iii) over Ln(iii)

A series of four water-soluble N,O-tetrapodal ligands derived from ethylenediamine, bearing hard acetate groups and soft N-heterocycles, either pyridine or pyrazine, was developed to study the impact of the softness of N-donors on the complexation properties with trivalent f ions. Two novel ligands of enhanced soft character, bearing three pyridines (L3py) or three pyrazines (L3pz), were synthesized and the related lanthanide complexes were studied in solution. The ligand containing three pyridylmethyl moieties L3py gives complexes with a coordination similar to EDTA, i.e. a hexadentate coordination mode as indicated by NMR and luminescence decays (q = 3) and stability constants in the range log β110 = 6.99-9.3 (La-Lu). On the other hand, the softest molecule L3pz forms much less stable complexes with log β110 = 4.0-4.4 (La-Eu). The selective back-extraction of Am(iii) from organic solutions containing 4f and 5f elements was tested with the four water-soluble complexing agents. The ligand L3pz demonstrates poor stripping ability and selectivity. In contrast, the three ligands Lpy, Lpz and L3py give interesting back-extraction results with Eu/Am separation factors ranging from 36 to 46, which are significantly higher than with HEDTA. This exemplifies the role of the N-heterocycle softness in enhancing the separation between Am(iii) and Eu(iii). Interestingly, the pyrazine-based ligand, Lpz, demonstrates the best stripping properties, with a distribution factor that approaches that of HEDTA in the same conditions (DAm ≈0.3). This molecule is a good compromise between softness and hardness and forms complexes still stable at pH 3 due to its low basicity.

Thermo-responsive extraction of cadmium(II) ion with TPEN-NIPA gel. Effect of the number of polymerizable double bond toward gel formation and the extracting behavior

N,N,N′,N′-(Tetrakis-2-pyridylmethyl)ethylenediamine (TPEN) derivatives bearing the different number (1-4) of a double bond moiety on the pyridine ring are synthesized and subjected to copolymerization with N-isopropylacrylamide in the presence of AIBN. The obtained poly(TPEN-NIPA) gels show thermo-responsive swelling/shrinking behaviors and are employed for the extraction of cadmium(II) ion from the aqueous solution to examine the relationship of the gel characteristics and the extraction performance. The polymer gels composed of the TPEN derivative bearing three or four double bonds exhibit temperature-dependent change of swelling and shrinking in water. These gels extract CdII ion efficiently from the aqueous solution in the swelling state at 5 °C, while little extraction was observed at 45 °C with shrinking.

Design and synthesis of zinc-selective chelators for extracellular applications

Zinc (Zn2+) is found in every cell in human bodies. A few millimolar of free Zn2+ exists in the vesicles of presynaptic neurons in the mammalian brain and is released by synaptic activity or depolarization, modulating the function of certain ion channels and receptors. Although various chemical tools for measuring Zn2+ in biological samples, such as fluorescent probes for Zn2+, have been developed, Zn2+-selective chelators have room to be improved. Research on Zn2+ signals in the brain has traditionally employed several chelators, which have several shortcomings for biological applications. Here we report the design, synthesis, and properties of new membrane-impermeable chelators selective for Zn2+ and describe biological applications in hippocampal slices. As a result, our newly designed chelator revealed the first biological implication that presynaptic Zn2+ can be released in the CA1 region. This confirms the utility of these new chelatotrs as extracellular Zn2+ chelators for biological applications. Copyright