104175-33-9 Usage
Uses
Used in Pharmaceutical Industry:
2,6-DIMETHYL-QUINOLINE-4-CARBOXYLIC ACID is used as a key intermediate in the synthesis of pharmaceutical drugs for its ability to contribute to the development of new medications with enhanced therapeutic properties.
Used in Organic Chemistry Research:
2,6-DIMETHYL-QUINOLINE-4-CARBOXYLIC ACID is used as a building block for the development of new compounds with biological activities, facilitating the creation of innovative molecules with potential applications in various fields.
Used in Medicinal Chemistry:
2,6-DIMETHYL-QUINOLINE-4-CARBOXYLIC ACID is used as a subject of study for its potential antioxidant and anti-inflammatory properties, which could lead to the discovery of new treatments for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 104175-33-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,1,7 and 5 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 104175-33:
(8*1)+(7*0)+(6*4)+(5*1)+(4*7)+(3*5)+(2*3)+(1*3)=89
89 % 10 = 9
So 104175-33-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H11NO2/c1-7-3-4-11-9(5-7)10(12(14)15)6-8(2)13-11/h3-6H,1-2H3,(H,14,15)/p-1
104175-33-9Relevant academic research and scientific papers
Synthesis of novel 2-methyl-4-carboxyquinolines, the new by-products of the Doebner reaction
Omidkhah, Negar,Ghodsi, Razieh
, p. 1947 - 1955 (2021/05/26)
The Doebner reaction is the chemical reaction of an aniline with an aldehyde and pyruvic acid to form quinoline-4-carboxylic acids. Although Doebner reaction is a simple procedure for synthesis of 4-carboxyquinolines, which the product precipitates from the reaction mixtures with high purity, its yield is not high due to the formation of different reaction by-products. In the present study we found a new by-product (2-methylquinoline-4-carboxilic acid derivative), in Doebner reaction. We synthesized new 2-methylquinoline-4-carboxilic acid derivatives simply by stirring pyruvic acid and aromatic amine in ethanol with high purity. Generally, we found that aniline derivatives possessing electron donating groups are needed for the synthesis of 2-methylquinoline-4-carboxilic acid derivatives in ethanol. 1H-NMR data of products revealed that this reaction is regioseletive and ring closure occurs on the position with less steric hindrance. The order of mixing of the reactants plays a key role in determining the type of products in the Doebner reaction.
