104189-64-2Relevant academic research and scientific papers
ANALOGS OF PYRIMIDINE NUCLEOSIDES. 19. SYNTHESIS, ANTINEOPLASTIC ACTIVITY, AND KINETICS OF THE HYDROLYSIS OF 1-(3-PHTHALIDYL)-5-FLUOROURACILS
Zhuk, R. A.,Ludzisha, A. S.,Shpaer, E. G.,Lidak, M. Yu.,Zidermane, A. A.,Meirena, D. V.
, p. 1159 - 1163 (1985)
1-(3-Phthalidyl)-5-fluorouracils were synthesized by alkylation of 2,4-bis(trimethylsilyl)-5-fluorouracil with substituted 3-bromophthalides, and the rate constants for hydrolysis at pH 8.0-11.5 were determined.The antineoplastic activity of a number of the compounds was established, and it was assumed that there is a relationship between the biological activity and the rate of hydrolysis.
