Chemistry of Heterocyclic Compounds p. 1159 - 1163 (1985)
Update date:2022-07-30
Topics:
Zhuk, R. A.
Ludzisha, A. S.
Shpaer, E. G.
Lidak, M. Yu.
Zidermane, A. A.
Meirena, D. V.
1-(3-Phthalidyl)-5-fluorouracils were synthesized by alkylation of 2,4-bis(trimethylsilyl)-5-fluorouracil with substituted 3-bromophthalides, and the rate constants for hydrolysis at pH 8.0-11.5 were determined.The antineoplastic activity of a number of the compounds was established, and it was assumed that there is a relationship between the biological activity and the rate of hydrolysis.
View MoreHangzhou Eastbiopharm Co.,Ltd.
Contact:+86-571-88931780
Address:Hangzhou,China
Dalian RSD International Trade Co.,Ltd.(expird)
Contact:86-22-60875058 58610575
Address:Wantong International Areas, Hongqiao District, Tianjin, China.China
Contact:+86-574-89075960
Address:#100 Xiang Yun Road, New High tech area, Ningbo, China
LINYI FUDE FINE CHEMICAL CO.,LTD
Contact:86-539-2361184
Address:YISHUI, LINYI,SAHNDONG,CHINA
QINGDAO ON-BILLION INDUSTRAIL CO.,LTD
website:http://www.obn.com.cn
Contact:+86-15005320811 +86-532-80681989
Address:F35 Parkson Mansion No.44-60 Zhongshan Rd.
Doi:10.1016/S0040-4039(01)84598-6
(1985)Doi:10.1016/j.tetasy.2008.04.022
(2008)Doi:10.1080/10587259408039195
(1994)Doi:10.1016/S0040-4020(01)89848-3
(1992)Doi:10.1021/co300104k
(2013)Doi:10.1016/j.tet.2007.07.032
(2007)
