Chemistry of Heterocyclic Compounds p. 1159 - 1163 (1985)
Update date:2022-07-30
Topics:
Zhuk, R. A.
Ludzisha, A. S.
Shpaer, E. G.
Lidak, M. Yu.
Zidermane, A. A.
Meirena, D. V.
1-(3-Phthalidyl)-5-fluorouracils were synthesized by alkylation of 2,4-bis(trimethylsilyl)-5-fluorouracil with substituted 3-bromophthalides, and the rate constants for hydrolysis at pH 8.0-11.5 were determined.The antineoplastic activity of a number of the compounds was established, and it was assumed that there is a relationship between the biological activity and the rate of hydrolysis.
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Doi:10.1016/S0040-4039(01)84598-6
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(2007)
