Chemistry of Heterocyclic Compounds p. 1159 - 1163 (1985)
Update date:2022-07-30
Topics:
Zhuk, R. A.
Ludzisha, A. S.
Shpaer, E. G.
Lidak, M. Yu.
Zidermane, A. A.
Meirena, D. V.
1-(3-Phthalidyl)-5-fluorouracils were synthesized by alkylation of 2,4-bis(trimethylsilyl)-5-fluorouracil with substituted 3-bromophthalides, and the rate constants for hydrolysis at pH 8.0-11.5 were determined.The antineoplastic activity of a number of the compounds was established, and it was assumed that there is a relationship between the biological activity and the rate of hydrolysis.
View Moreguide(suzhou) fine materials co. ltd
Contact:0512-80972173
Address:21st Building, No.369 Lushan Rd, New District Suzhou China 215129
Chengdu Pukang Biotechnology Co., Ltd
Contact:+86-28-82550498
Address:No. 558 Rulin Road,Xinjin county,Chengdu city, China
Contact:86+21-56421993
Address:3F,BUILDING 10,NO.2889 JINKE ROAD, SHANGHAI.
Shanxi Tongji Pharmaceuticals Co., Ltd.
Contact:+86-359-3024784
Address:Xikuang South Road, Ruicheng County , Shanxi
Shanghai Gsyn Chemical Co.,Ltd.
Contact:86-021-67158290
Address:86-021-67158291
Doi:10.1016/S0040-4039(01)84598-6
(1985)Doi:10.1016/j.tetasy.2008.04.022
(2008)Doi:10.1080/10587259408039195
(1994)Doi:10.1016/S0040-4020(01)89848-3
(1992)Doi:10.1021/co300104k
(2013)Doi:10.1016/j.tet.2007.07.032
(2007)
