104199-71-5Relevant articles and documents
The synthesis and inhibitory activity of dethiotrypanothione and analogues against trypanothione reductase
Czechowicz, Josephine A.,Wilhelm, April K.,Spalding, Maroya D.,Larson, Anna M.,Engel, Linnea K.,Alberg, David G.
, p. 3689 - 3693 (2007)
(Chemical Equation Presented) Trypanothione reductase (TR) catalyzes the NADPH-dependent reduction of trypanothione disulfide (1). TR plays a central role in the trypanosomatid parasite's defense against oxidative stress and has emerged as a promising tar
Synthesis and NMR Characterization of the Trypanosomatid Metabolite, N1,N8-Bis(glutathionyl)spermidine Disulphide (Trypanothione Disulphide)
Henderson, Graeme B.,Glushka, John,Cowburn, David,Cerami, Anthony
, p. 911 - 914 (2007/10/02)
An optimized chemical synthesis of the novel trypanosomatid metabolite, N1,N8-bis(glutathionyl)spermidine (trypanothione disulphide) is described, and its solution structure has been investigated by NMR spectroscopy.The 1H, 13C, and