104199-72-6Relevant academic research and scientific papers
The synthesis and inhibitory activity of dethiotrypanothione and analogues against trypanothione reductase
Czechowicz, Josephine A.,Wilhelm, April K.,Spalding, Maroya D.,Larson, Anna M.,Engel, Linnea K.,Alberg, David G.
, p. 3689 - 3693 (2008/02/04)
(Chemical Equation Presented) Trypanothione reductase (TR) catalyzes the NADPH-dependent reduction of trypanothione disulfide (1). TR plays a central role in the trypanosomatid parasite's defense against oxidative stress and has emerged as a promising tar
Synthesis and NMR Characterization of the Trypanosomatid Metabolite, N1,N8-Bis(glutathionyl)spermidine Disulphide (Trypanothione Disulphide)
Henderson, Graeme B.,Glushka, John,Cowburn, David,Cerami, Anthony
, p. 911 - 914 (2007/10/02)
An optimized chemical synthesis of the novel trypanosomatid metabolite, N1,N8-bis(glutathionyl)spermidine (trypanothione disulphide) is described, and its solution structure has been investigated by NMR spectroscopy.The 1H, 13C, and
