1042-35-9

Basic information

• Product Name: 1-benzyl-4-(cyclohexylamino)piperidine-4-carboxamide
• Synonyms: 1-benzyl-4-(cyclohexylamino)piperidine-4-carboxamide;N-Benzyl-4-carbamyl-4-N-(cyclohexy;4-Cyclohexylamino-1-phenylmethyl-4-piperidinecarboxamide;1-(benzyl)-4-(cyclohexylamino)isonipecotamide;4-(cyclohexylamino)-1-(phenylmethyl)piperidine-4-carboxamide
• CAS NO: 1042-35-9
• Molecular Formula: C₁₉H₂₉N₃O
• Molecular Weight: 315.45306
• EINECS: 213-869-8
• Mol File: 1042-35-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 138.8-139.6 °C
• Boiling Point: 495.3°Cat760mmHg
• Flash Point: 253.4°C
• Appearance: /
• Density: 1.12g/cm³
• Vapor Pressure: 5.97E-10mmHg at 25°C
• Refractive Index: 1.584
• PKA: 15.90±0.20(Predicted)
• CAS DataBase Reference: 1-benzyl-4-(cyclohexylamino)piperidine-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-4-(cyclohexylamino)piperidine-4-carboxamide(1042-35-9)
• EPA Substance Registry System: 1-benzyl-4-(cyclohexylamino)piperidine-4-carboxamide(1042-35-9)

Safety Data

• Hazardous Substances Data: 1042-35-9(Hazardous Substances Data)

Usage

General Description

1-Benzyl-4-(cyclohexylamino)piperidine-4-carboxamide is a chemical compound with the molecular formula C23H32N2O. It is a piperidine derivative and an amide. 1-benzyl-4-(cyclohexylamino)piperidine-4-carboxamide has potential applications in the pharmaceutical industry, particularly in the development of new medications for various medical conditions. It is a white solid that is soluble in organic solvents. Its structural features make it a potentially valuable building block for creating new drug candidates. However, further research and testing are required to fully determine its potential applications and properties.

InChI:InChI=1/C19H29N3O/c20-18(23)19(21-17-9-5-2-6-10-17)11-13-22(14-12-19)15-16-7-3-1-4-8-16/h1,3-4,7-8,17,21H,2,5-6,9-15H2,(H2,20,23)

Upstream product

• 968-85-4 1-benzyl-4-cyclohexylamino-piperidine-4-carbonitrile 
• 108-91-8 cyclohexylamine 
• 3612-20-2 1-phenylmethyl-4-piperidone 

Downstream Products

• 1045-16-5 8-benzyl-1-cyclohexyl-1,3,8-triaza-spiro[4.5]dec-2-en-4-one 
• 180386-39-4 3-Carboxymethyl-1-cyclohexyl-4-oxo-1,3,8-triaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester 
• 1025911-89-0 1-Cyclohexyl-3-methoxycarbonylmethyl-4-oxo-1,3,8-triaza-spiro[4.5]decane-8-carboxylic acid tert-butyl ester 

Relevant articles and documents

Synthesis and characterization of pseudopeptide bradykinin B2 receptor antagonists containing the 1,3,8-triazaspiro[4.5]decan-4-one ring system

A series of pseudopeptides containing alkyl-, cycloalkyl-, aryl-, and aralkyl-substituted 1,3,8-triazaspiro[4.5]decan-4-one-3-acetic acids as amino acid surrogates to replace the Pro2-Pro3-Gly4-Phe5 section of the peptide bradykinin B2 receptor antagonist [Pro3, Phe5]HOE 140 (D-Arg0-Arg1- Pro2-Pro3-Gly4-Phe5-Ser6-D-Tic7-Oic8-Arg9) were prepared. These psuedopeptides were examined in vitro for their B2 receptor affinities as well as for their ability to block bradykinin mediated actions in vivo. Two compounds in particular, NPC 18521 (I) and NPC 18688 (V) were quite potent in these latter assays, indicating that a significant portion of this prototypical second generation decapeptide antagonist can be replaced with a more compact nonpeptide molecule.