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8-Benzyl-1-cyclohexyl-1,3,8-triaza-spiro[4.5]dec-2-en-4-one is a complex organic compound with a molecular formula of C18H24N3O. It is a heterocyclic compound, featuring a spiro structure with a cyclohexane ring and a triazadecane ring connected through a spiro carbon atom. The compound has a benzyl group attached to the nitrogen atom of the triazadecane ring and a cyclohexyl group attached to the carbon atom of the triazadecane ring. The enone functional group is present at the 2-position of the spiro structure, and a ketone group is present at the 4-position. 8-benzyl-1-cyclohexyl-1,3,8-triaza-spiro[4.5]dec-2-en-4-one is of interest in the field of organic chemistry and may have potential applications in pharmaceuticals or materials science due to its unique structure and properties.

1045-16-5

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1045-16-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1045-16-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,0,4 and 5 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1045-16:
(6*1)+(5*0)+(4*4)+(3*5)+(2*1)+(1*6)=45
45 % 10 = 5
So 1045-16-5 is a valid CAS Registry Number.

1045-16-5Relevant academic research and scientific papers

Synthesis and characterization of pseudopeptide bradykinin B2 receptor antagonists containing the 1,3,8-triazaspiro[4.5]decan-4-one ring system

Mavunkel, Babu J.,Lu, Zhijian,Goehring, R. Richard,Lu, Songfeng,Chakravarty, Sarvajit,Perumattam, John,Novotny, Elizabeth A.,Connolly, Maureen,Valentine, Heather,Kyle, Donald J.

, p. 3169 - 3173 (2007/10/03)

A series of pseudopeptides containing alkyl-, cycloalkyl-, aryl-, and aralkyl-substituted 1,3,8-triazaspiro[4.5]decan-4-one-3-acetic acids as amino acid surrogates to replace the Pro2-Pro3-Gly4-Phe5 section of the peptide bradykinin B2 receptor antagonist [Pro3, Phe5]HOE 140 (D-Arg0-Arg1- Pro2-Pro3-Gly4-Phe5-Ser6-D-Tic7-Oic8-Arg9) were prepared. These psuedopeptides were examined in vitro for their B2 receptor affinities as well as for their ability to block bradykinin mediated actions in vivo. Two compounds in particular, NPC 18521 (I) and NPC 18688 (V) were quite potent in these latter assays, indicating that a significant portion of this prototypical second generation decapeptide antagonist can be replaced with a more compact nonpeptide molecule.

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