10420-20-9Relevant academic research and scientific papers
Organic Nanocrystals with Bright Red Persistent Room-Temperature Phosphorescence for Biological Applications
Fateminia, S. M. Ali,Mao, Zhu,Xu, Shidang,Yang, Zhiyong,Chi, Zhenguo,Liu, Bin
, p. 12160 - 12164 (2017)
Persistent room-temperature phosphorescence (RTP) in pure organic materials has attracted great attention because of their unique optical properties. The design of organic materials with bright red persistent RTP remains challenging. Herein, we report a n
A single-layer approach to electrochromic materials
Percec, Simona,Tilford, Susan
, p. 361 - 368 (2011)
This study is focused on the development of electrochromic (EC) materials that could be incorporated into electrically-driven switchable devices such as electrochromogenic glasses. The ultimate goal of this research is to depart from the complexity of the EC device construction which is in use today. Such construction consists of three layers each of them incorporating a specific functionality: the electrochromophore, the electrolyte and the ion storage, assembled between two transparent or reflective electrodes. In most of these conventional devices the electrolyte layer is a liquid or a gel. Since solid-state EC devices are of high commercial interest, we are exploring various avenues to reduce the number of layers to one layer that is all-solid and electrochromically/electrolytically and ionically functional. The design strategy is based on the use of polymers such as poly(epichlorohydrin-co- ethylene oxide), poly(vinyl butyral) and poly(ethylene-co-methacrylic acid) ionomer, to which EC properties were introduced by grafting reactions with specifically synthesized carbazole derivatives. A combination of analytical techniques was used to characterize the monomers and the carbazole-grafted polymers. A proof of concept was demonstrated for a single-layer, all-solid-state EC device consisting of a film of poly(ECH-co-EO) containing pendent carbazole groups, assembled between two transparent electrodes, Sn-doped In2O3 oxide-coated glasses.
Synthesis and spectroscopic characterisation of (E)-2-(2-(9-(4-(1H-1,2,4- triazol-1-yl)butyl)-9H-carbazol-3-yl)vinyl)-3-ethylbenzo[d]thiazol-3-ium, a new ligand and potential DNA intercalator
Gluszynska, Agata,Rajczak, Ewa,Juskowiak, Bernard
, p. 1231 - 1239 (2013)
Three new compounds based on carbazole planar skeleton were synthesised. Among them there is a new ligand and a potential DNA intercalator which contains a benzothiazolium moiety connected to the carbazole ring by a vinyl bridge. The absorption and emission spectral properties of this new ligand have been studied by spectroscopic methods.
Synthesis and polymerization of 9-carbazolyl-containing 1-silacyclobutane derivatives
Ushakov, N. V.,Pritula, N. A.,Rebrov, A. I.
, p. 1372 - 1376 (1993)
Novel 9-carbazolyl-containing 1-silacyclobutane derivatives containing tri-, tetra-, and pentamethylene bridges between the nitrogen and silicon atoms and 1-methyl-1-p-phenyl-1-silacyclobutane have been synthesized.Polymeri
An attempt to modify nonlinear optical effects of polyurethanes by adjusting the structure of the chromophore moieties at the molecular level using "click" chemistry
Li, Zhong'an,Zeng, Qi,Li, Zhen,Dong, Shoucheng,Zhu, Zhichao,Li, Qianqian,Ye, Cheng,Di, Chong'an,Liu, Yunqi,Qin, Jingui
, p. 8544 - 8546 (2006)
The modification of the nonlinear optical effects (NLO) properties of polyurethanes by adjusting the structure of chromophore moieties at the molecular level by introducing different size of isolation spacers, was illustrated. One of the major problems arising while optimizing organic NLO materials is to efficiently translate the large β values of the organic chromophores into high macroscopic NLO activities of polymers. The isolation parts in the chromophore moieties can weaken the strong intermolecular electrostatic interaction to enhance the resultant macroscopic NLO effect of polymers. The dynamic thermal stabilities of the NLO activities of the polymers are investigated by depoling experiments where the real time decays of their SHG signals are monitored. The results show that the NLO properties do not always increase accompanying with the entanglement of the isolation groups linked to the corresponding chromophore moieties.
New dimeric carbazole-benzimidazole mixed ligands for the stabilization of human telomeric G-quadruplex DNA and as telomerase inhibitors. A remarkable influence of the spacer
Maji, Basudeb,Kumar, Krishan,Muniyappa,Bhattacharya, Santanu
, p. 8335 - 8348 (2015)
The development of G-quadruplex (G4) DNA binding small molecules has become an important strategy for selectively targeting cancer cells. Herein, we report the design and evolution of a new kind of carbazole-based benzimidazole dimers for their efficient telomerase inhibition activity. Spectroscopic titrations reveal the ligands high affinity toward the G4 DNA with significantly higher selectivity over duplex-DNA. The electrophoretic mobility shift assay shows that the ligands efficiently promote the formation of G4 DNA even at a lower concentration of the stabilizing K+ ions. The TRAP-LIG assay demonstrates the ligand's potential telomerase inhibition activity and also establishes that the activity proceeds via G4 DNA stabilization. An efficient nuclear internalization of the ligands in several common cancer cells (HeLa, HT1080, and A549) also enabled differentiation between normal HFF cells in co-cultures of cancer and normal ones. The ligands induce significant apoptotic response and antiproliferative activity toward cancer cells selectively when compared to the normal cells.
Multi-layered hybrid perovskites templated with carbazole derivatives: Optical properties, enhanced moisture stability and solar cell characteristics
Herckens, Roald,Van Gompel, Wouter T. M.,Song, Wenya,Gélvez-Rueda, María C.,Maufort, Arthur,Ruttens, Bart,D'Haen, Jan,Grozema, Ferdinand C.,Aernouts, Tom,Lutsen, Laurence,Vanderzande, Dirk
, p. 22899 - 22908 (2018)
Research into 2D layered hybrid perovskites is on the rise due to the enhanced stability of these materials compared to 3D hybrid perovskites. Recently, interest towards the use of functional organic cations for these materials is increasing. However, a vast amount of the parameter space remains unexplored in multi-layered (n > 1) hybrid perovskites for solar cell applications. Here, we incorporate carbazole derivatives as a proof of concept towards the use of tailored functional molecules in multi-layered perovskites. Films of low-n carbazole containing perovskites show high photoconductivity half-lifetimes. Higher-n (?n? = 40) multi-layered perovskite films possess charge carrier diffusion lengths comparable to MAPI thin films. Solar cells containing these materials have comparable efficiencies to our MAPI and phenethylammonium (PEA)-containing multi-layered perovskite reference devices. Moisture stability tests were performed both at the material and device levels. In comparison to MAPI and PEA-based materials and solar cells, the addition of a small percentage of the carbazole derivative to the perovskite material significantly enhances the moisture stability.
Infrared-emitting poly(norbornene)s and poly(cyclooctene)s
Meyers, Amy,Kimyonok, Alpay,Weck, Marcus
, p. 8671 - 8678 (2005)
Poly(norbornene)- and poly(cyclooctene)-based copolymers, bearing carbazole and 8-hydroxy-quinoline side chains, were prepared. Upon complexation of the pendant quinoline ligands in the side chain with ytterbium followed by the addition of 2 equiv of additional quinolines, infrared-emitting copolymers that emit around 970 nm were obtained. The emission intensities increased linearly as the density of lanthanide-quinolate complexes increased in the copolymers. Finally, we were able to prove that the polymer backbones do not interfere with the optical properties of the polymers, suggesting that these polymers are outstanding materials as IR emitters.
Carbazole-based gold(i) complexes with alkyl chains of different lengths: Tunable solid-state fluorescence, aggregation-induced emission (AIE), and reversible mechanochromism characteristics
Chen, Zhao,Yang, Lan,Hu, Yuxuan,Wu, Di,Yin, Jun,Yu, Guang-Ao,Liu, Sheng Hua
, p. 93757 - 93764 (2015)
In this paper, seven carbazole-based mononuclear gold(i) complexes with alkyl chains of different lengths have been synthesized and reported. All of these gold(i) complexes exhibit outstanding AIE characteristics. Furthermore, these various solid-state light-emitting AIE-active gold(i) complexes all show reversible mechanochromic fluorescent behaviors. The possible mechanism explaining these interesting AIE and mechanochromism phenomena involves a variation in weak multiple intermolecular C-H...F and π...π interactions and the formation or alteration of aurophilic interactions.
Design, synthesis and biological activity evaluation of novel carbazole-benzylpiperidine hybrids as potential anti Alzheimer agents
Edraki, Najmeh,Faghih, Zeinab,Iraji, Aida,Nadri, Hamid,Rezaei, Zahra,Sadeghian, Batool,Sadeghian, Issa,Sakhteman, Amirhossein
, (2020)
Alzheimer's disease (AD) as the most common form of dementia in aged people, is an intricate neurodegenerative disease. Therefore, a novel strategy so-called multi-target-directed ligand has received much attention for the effective treatment of AD. In this study a series of novel carbazole-benzylpiperidine hybrids 9a-m was designed, synthesized and evaluated as acetylcholinesterase and butyrylcholinesterase inhibitors. Moreover, some of these compounds were evaluated for anti β-secretase (BACE1) activity and metal chelation properties. Among the synthesized compounds, compounds 9b (IC50 = 16.5 μM for AChE and IC50 = 0.59 μM for BuChE) and 9c (IC50 = 26.5 μM for AChE and IC50 = 0.18 μM for BuChE) showed the highest inhibitory activity against acetylcholinesterase and butyrylcholinesterase. Furthermore, these compounds (9b and 9c) displayed interaction with Zn2+ ion and compound 9c showed moderate inhibitory activity against BACE1 (24.5% at 50 μM). Kinetic and docking studies exhibited that these compounds likely act as a non-competitive inhibitor able to interact with the catalytic active site (CAS) and peripheral anionic site (PAS) of acetylcholinesterase simultaneously.
