10420-99-2

Basic information

• Product Name: Ethanone, 1-(4-chlorophenyl)-2-(2-pyridinyl)-
• CAS NO: 10420-99-2
• Molecular Formula: C13H10ClNO
• Molecular Weight: 231.681
• Mol File: 10420-99-2.mol

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(4-chlorophenyl)-2-(2-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4-chlorophenyl)-2-(2-pyridinyl)-(10420-99-2)
• EPA Substance Registry System: Ethanone, 1-(4-chlorophenyl)-2-(2-pyridinyl)-(10420-99-2)

Safety Data

• Hazardous Substances Data: 10420-99-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
Ethanone, 1-(4-chlorophenyl)-2-(2-pyridinyl)-, is utilized as a compound in pharmaceutical research and development due to its distinctive structural features and potential pharmacological properties. Its chlorophenyl and pyridinyl groups may contribute to its interaction with biological targets, offering opportunities for the development of new therapeutic agents.
Used in Organic Synthesis Reactions:
Ethanone, 1-(4-chlorophenyl)-2-(2-pyridinyl)-, also serves as a reagent in organic synthesis reactions. Its ketone functional group and attached aromatic rings provide a versatile platform for various chemical transformations, enabling the synthesis of a range of organic compounds with potential applications in different industries.
Used in Chemical Research:
Ethanone, 1-(4-chlorophenyl)-2-(2-pyridinyl)-, is employed in chemical research to study its biological activity and toxicological effects. Understanding these properties is crucial for assessing its suitability and safety in potential applications, such as drug development or as a reagent in organic synthesis.

Upstream product

• 1749-29-7 2-pyridylmethyllithium 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 109-06-8 α-picoline 
• 623-03-0 4-Cyanochlorobenzene 
• 17881-80-0 (2-picolyl)trimethylsilane 
• 122334-37-6 4-chloro-N-methoxy-N-methylbenzamide 
• 80221-12-1 2-(4-chloro-phenylethynyl)-pyridine 

Downstream Products

• 1435892-96-8 2-(4-chlorophenyl)-4H-quinolizin-4-one 

Relevant articles and documents

Chiroptical, Structural and Catalytic Properties of S-α-Methyl-benzylamines and their Rh(I) and Cu(I) Complexes

S-α-Methyl-benzylamines 15-21 and their Rh(I) complexes 22-28 are prepared and their chiroptical and conformational properties are studied.Free ligands are present as enamines in the solution and in the solid state, but are bound to Rh(I) in the imine form.The CD spectra confirm that complexation of 15-21 induces both structural change and strong conformational perturbations.The molecular structures in the crystal are reported for the chiral 1,5-bisnitrogen ligand 18, and its Rh perchlorate complex 25.The absolute conformation of the chromophore in 18 inverts on binding to Rh(I) in 25.The value of the torsional angle about C10-C9-C16-C21 bond (- 69.7 deg) in 18, which defines the twisted stilbene-like chromophore, turns for 25 into 75.0 deg.Chiral (S)-(-)-methylbenzyl subunit in 18 has a C1-N1-C9-C10 torsional angle of 175.2 deg, whereas on binding to Rh(I) in 25 this angle changes to -178.4 deg.The absolute conformation around the styrene-like arrangement of the bonds in 15-21 can be deduced from the strong positive Cotton effect at ca. 350 nm.Cyclopropanation of styrene with ethyl diazoacetate, in the presence of in situ generated Cu(I) complexes of chiral 1,5-bidentate ligands 15-21, yielded cis/trans 2-phenylcyclopropan-1-carboxylic acid ethylesters with 5-21percent e.e.Though generally low, the enantioselectivity was somewhat higher for ortho-(16-18) than for para-(19-21) substituted phenyl derivatives.

Synthesis of functionalised 4H-quinolizin-4-ones via tandem Horner-Wadsworth-Emmons olefination/cyclisation

4H-Quinolizin-4-ones are a unique class of heterocycle with valuable physicochemical properties and which are emerging as key pharmacophores for a range of biological targets. A tandem Horner-Wadsworth-Emmons olefination/cyclisation method has been developed to allow facile access to substituted 4H-quinolizin-4-ones encoded with a range of functional groups.

Substituent and temperature controlled tautomerism of 2-phenacyl-pyridine: The hydrogen bond as a configurational lock of (Z)-2-(2-hydroxy-2-phenylvinyl)pyridine

2-Phenacylpyridines substituted in the benzene ring are in equilibrium with (Z)-2-(2-hydroxy-2-phenylvinyl)pyridines when dissolved in chloroform. The substituent affects significantly the tautomeric equilibrium [the amount of the enolimine form stabilized by the intramolecular hydrogen bond is 1 and 92% for R = p-N(CH2)4 and p-NO2, respectively]. The negative logarithm of the tautomeric equilibrium constant, KT, is linearly dependent on the Hammett σ substituent constants. The dependence of KT vs. temperature is exponential in character: the more electron-withdrawing is the substituent, the more distinct is the influence of temperature. Unexpectedly, the tautomer present in the crystalline state is not the same for all compounds studied (it is the ketimine one for those carrying strong electron-donor groups). Among the different ab initio methods used to calculate the enthalpy of the proton transfer in chloroform solution, MP2/6-31G** gives the best results.

CONVENIENT METHOD FOR THE PREPARATION OF 2-PHENACYLPYRIDINES

2-Phenacylpyridines (3) were prepared from 2-(trimethylsilylmethyl)pyridine (1) and p-substituted benzonitriles (2) (X = H, Cl CH3, OCH3) in high yields (70 ca. 90percent)under a mild condition (LDA/THF, -75 deg C).The method was compared with a reaction of α-picoline with (2) under the same condition.The keto-enol tautomerism of (3) were also discussed by means of the nmr spectra.