104206-15-7

Upstream product

• 67-56-1 methanol 
• 104265-73-8 rac-(2S,3S)-5-allyl-6-hydroxy-2-(3,4-dimethoxyphenyl)-3-methyl-2,3-dihydrobenzofuran 
• 546-67-8 lead(IV) tetraacetate 
• 18523-76-7 (E)-3',4'-dimethoxycinnamyl alcohol 
• 1616-51-9 3-allyloxyphenol 
• 108-46-3 recorcinol 
• 104206-13-5 3,4-dimethoxycinnamyl 3-(allyloxy)phenyl ether 
• 14737-89-4 3,4-dimethoxy-trans-cinnamic acid 

Relevant academic research and scientific papers

Structure-Activity Relationships of Kadsurenone Analogues

Kadsurenone, a specific receptor antagonist of platelet-activating factor (PAF), and its analogues were prepared from derivatives of cinnamyl alcohol and (allyloxy)phenol.Racemic kadsurenone, resolvable by a Chiralpak column at low temperatures, has an IC50 value of 2 * 10-7 M, which is about 50percent of the activity of the natural product (IC50 = 1 * 10-7 M).The structural specificity of kadsurenone was further demonstrated by the low PAF-receptor-blocking activities of denudatin B, mirandin A, desallylkadsurenone, and the 2-epimer of kadsurenone.

TOTAL SYNTHESIS OF KADSURENONE AND ITS ANALOGS

Kadsurenone, a specific receptor antagonist of platelet-activating factor and a natural product isolated from Piper futokadsura was prepared in three steps from 3,4-dimethoxycinnamyl alcohol and allyloxyphenol via rac-(2S,3S)-5-allyl-6-hydroxy-2-(3,4-dime