104209-12-3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 52520-37-3 (3-Methoxybenzyl alcohol)chromium Tricarbonyl 
• 85370-85-0 N,N-diethyl-3-methoxy-2-(trimethylsilyl)benzamide 

Downstream Products

• 113337-60-3 (2-Chloromethyl-6-methoxy-phenyl)-trimethyl-silane 
• 113337-64-7 3-(2-Bromo-3-methoxy-phenyl)-propionic acid 
• 113337-63-6 3-(3-Methoxy-2-trimethylsilanyl-phenyl)-propionaldehyde 
• 113337-67-0 3-(2-Bromo-3-methoxy-phenyl)-2,2-dimethyl-propionic acid 
• 113337-66-9 3-(2-Bromo-3-methoxy-phenyl)-2-methyl-propionic acid 
• 113337-57-8 3-(3-Methoxy-2-trimethylsilanyl-phenyl)-2,2-dimethyl-propionaldehyde 
• 113337-56-7 3-(3-Methoxy-2-trimethylsilanyl-phenyl)-2-methyl-propionaldehyde 
• 113337-62-5 3-(3-Methoxy-2-trimethylsilanyl-phenyl)-propionic acid ethyl ester 
• 113337-55-6 3-(3-Methoxy-2-trimethylsilanyl-phenyl)-2-methyl-propionic acid ethyl ester 
• 113337-65-8 3-(3-Methoxy-2-trimethylsilanyl-phenyl)-2,2-dimethyl-propionic acid ethyl ester 
• 113337-61-4 3-Methoxy-2-trimethylsilanyl-benzaldehyde 

Relevant academic research and scientific papers

OVERRIDING NORMAL FRIEDEL-CRAFTS REGIOCHEMISTRY IN CYCLIACYLATION. REGIOSPECIFIC CARBODESILYLATION AND PARHAM CYCLIZATION ROUTES TO 7-METHOXY-1-INDANOLS

Regiospecific syntheses of 7-methoxy-1-indanols (11a-c) and indanones (13a-c) via fluoride-induced carbodesilylation and Parham cyclization processes respectively are reported.

Arene-Metal Complex in Organic Synthesis: Directed Regioselective Lithiation of (?-Substituted benzene)chromium Tricarbonyl Complexes

(3-Methoxybenzyl alcohol)chromium tricarbonyl complex (8) and (2-substituted 7-methoxy-1-tetralol)chromium complexes 14-17 are selectively lithiated at the 4-position and 6-position, respectively, by treatment with n-BuLi/TMEDA.The regioselectivity of this lithiation is improved with increasing bulk of the butyllithium reagent employed.Since the direct lithiation of the corresponding chromium-free arenes normally proceeds at the 2- and 8-positions, complementarily substituted arenes can be prepared by using chromium tricarbonyl complexes.The different lithiation is explained by the relative configuration of the chromium tricarbonyl group in the (?-arene)Cr(CO)3 complexes and the electrostatic factor.This rationalization is supported, at least in part, by X-ray crystallography of the complex 16.On the other hand, the chromium complexes of arenes without a free hydroxyl group, such as benzyl methyl ether or ethylene acetals of benzaldehydes, are lithiated at the 2-position preferentially.