104214-61-1

Basic information

• Product Name: 3-Oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide
• Synonyms: 3-Oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide
• CAS NO: 104214-61-1
• Molecular Weight: 316.444
• Mol File: 104214-61-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-Oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide(104214-61-1)
• EPA Substance Registry System: 3-Oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide(104214-61-1)

Safety Data

• Hazardous Substances Data: 104214-61-1(Hazardous Substances Data)

Usage

Uses

(5α,17β)-3-Oxo-4-azaandrost-1-ene-17-carboxamide is an unsaturated 4-?azasteroids as human 5α-?reductase inhibitors.

Upstream product

• 98319-26-7 finasteride 

Downstream Products

• 1796930-46-5 dutasteride 

Relevant articles and documents

Isolation and structural characterization of degradation products of finasteride by preparative HPLC, HRMS and 2D NMR

Finasteride is a 5-α-reductase inhibitor with a steroidal skeleton and an amide group in its structure. It was subjected to forced degradation to observe its stability under stress conditions according to ICH guidelines. It was found to be stable to base and peroxide. However, in acid medium, three degradation products were observed. All of them were isolated from the reaction mixture by preparative HPLC. Their structures were elucidated by extensive analysis of 1D, 2D NMR spectra and HRMS. To best of our knowledge, none of them have been reported elsewhere.