1796930-46-5

Basic information

• Product Name: Dutasteride Impurity E (Dutasteride 17-alfa-epimer)
• Synonyms: Dutasteride Impurity E (Dutasteride 17-alfa-epimer);JWJOTENAMICLJG-UWKVNAJESA-N;(4aR,4bS,6aS,7R,9aS,9bS,11aR)-N-(2,5-bis(trifluoromethyl)phenyl)-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide
• CAS NO: 1796930-46-5
• Molecular Formula: C27H30F6N2O2
• Molecular Weight: 528.5297192
• Mol File: 1796930-46-5.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Dutasteride Impurity E (Dutasteride 17-alfa-epimer)(CAS DataBase Reference)
• NIST Chemistry Reference: Dutasteride Impurity E (Dutasteride 17-alfa-epimer)(1796930-46-5)
• EPA Substance Registry System: Dutasteride Impurity E (Dutasteride 17-alfa-epimer)(1796930-46-5)

Safety Data

• Hazardous Substances Data: 1796930-46-5(Hazardous Substances Data)

Usage

Uses

17α-Dutasteride (Dutateride EP Impurity E) is an impurity of Dutasteride (D735000), a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000).

Upstream product

• 328-92-7 2-iodo-1,4-bis-(trifluoromethyl)-benzene 
• 104214-61-1 3-Oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide 
• 328-93-8 2,5-bis(trifluoromethyl)aniline 
• 103335-41-7 methyl 3-oxo-4-aza-5α-androst-1-ene-17β-carboxylate 
• 1416955-18-4 3,5-seco-4-norpregn-5,20-dioxo-3-(ethoxycarbonyl)carboxylate 
• 104239-97-6 3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylic acid 
• 149198-45-8 methyl (2α,5α,17β)-2-iodo-3-oxo-4-aza-5-androstane-17-carboxylate 
• 3510-20-1 3,5-seco-4-norpregn-5,20-dion-3-carboxylic acid 
• 1416955-20-8 (2α,5α,17β)-N-[2,5-bis(trifluoromethyl)phenyl]-2-iodo-3-oxo-4-aza-5-androstane-17-carboxamide 
• 1416955-22-0 (5α,17β)-3-oxo-4-azaandrost-1-ene-17-(ethoxycarbonyl)carboxylate 
• 164656-22-8 (5α,17β)-N-[2,5-bis(trifluoromethyl)-phenyl]-3-oxo-4-aza-5-androstane-17-carboxamide 
• 1416955-19-5 (5α,17β)-3-oxo-4-aza-5-androstane-17-(ethoxycarbonyl)-carboxylate 
• 57-83-0 Progesterone 
• 103335-55-3 3-oxo-4-aza-5α-androstane-17β-carboxylic acid 

Relevant articles and documents

A method of preparation he male amine

The invention belongs to the field of pharmaceutical chemistry, and relates to a high-yield method for preparing dutasteride, which comprises the following steps: (1) under the action of a catalyst, reacting aza-5-androst-1-alkenyl-3-keto-17beta-carboxylic acid (I) with alcohol to generate 4-aza-5-androst-1-alkenyl-3-keto-17beta-carboxylate (II); and (2) in the presence of a catalyst, reacting the 4-aza-5-androst-1-alkenyl-3-keto-17beta-carboxylate (II) with 2,5-ditrifluoromethylaniline in an organic solvent at certain reaction temperature to obtain the dutasteride (III) at high yield. The method has the characteristics of accessible raw material, mild reaction conditions and high product yield, and is easy to control.

A high-pure undistilled he male amine preparation method (by machine translation)

The invention discloses a high-pure undistilled he male amine preparation method, the dutasteride in acetonitrile residue is ≤ 0.04%, type V impurity residual ≤ 0.02%, total impurity ≤ 0.15%. The preparation method comprises dutasteride crude synthesis an