1042159-61-4

Basic information

• Product Name: 3-(4-hydroxyphenyl)indolin-2-one
• Synonyms: 3-(4-hydroxyphenyl)indolin-2-one
• CAS NO: 1042159-61-4
• Molecular Weight: 225.247
• Mol File: 1042159-61-4.mol

Chemical Properties

• CAS DataBase Reference: 3-(4-hydroxyphenyl)indolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-hydroxyphenyl)indolin-2-one(1042159-61-4)
• EPA Substance Registry System: 3-(4-hydroxyphenyl)indolin-2-one(1042159-61-4)

Safety Data

• Hazardous Substances Data: 1042159-61-4(Hazardous Substances Data)

Upstream product

• 3265-29-0 3-diazo-indolin-2-one 
• 108-95-2 phenol 
• 35438-06-3 diethyl (2-oxoindolin-3-yl) phosphate 

Relevant articles and documents

Synthesis of α-Aryl Oxindoles by Friedel-Crafts Alkylation of Arenes

α-Aryl oxindoles are accessed from isatin via a two-step procedure involving a phospha-Brook rearrangement and a Friedel-Crafts alkylation in a one-pot procedure. The use of 1,1,1,3,3,3-hexafluoro-2-propanol as solvent significantly extended the reaction

Highly site-selective direct C-H bond functionalization of phenols with α-aryl-α-diazoacetates and diazooxindoles via gold catalysis

An unprecedented direct C-H bond functionalization of unprotected phenols with α-aryl α-diazoacetates and diazooxindoles was developed. A tris(2,4-di-tert-butylphenyl) phosphite derived gold complex promoted the highly chemoselective and site-selective C-H bond functionalization of phenols and N-acylanilines with gold-carbene generated from the decomposition of diazo compounds, furnishing the corresponding products in moderate to excellent yields at rt. The salient features of this reaction include readily available starting materials, unprecedented C-H functionalization rather than X-H insertion, good substrate scope, mild conditions, high efficiency, and ease in further transformation. To the best of our knowledge, this is the first example of C-H functionalization of unprotected phenols with diazo compounds.