104220-99-7

Upstream product

• 497-23-4 2-buten-4-olide 
• 85250-56-2 (trans-Oct-2-enyl) phenyl sulfide 
• 41349-38-6 methyl 7-bromohept-5-ynoate 
• 930-69-8 sodium thiophenolate 
• 3391-86-4 1-octen-3-ol 

Downstream Products

• 114144-31-9 methyl 13-(benzenesulfonyl)-9-oxo-10-oxaprost-14-en-5-ynoate 
• 56003-34-0 methyl (8R*,12R*,13E,15S*)-15-hydroxy-9-oxo-10-oxaprost-13-en-5-ynoate 
• 56003-34-0 methyl (8R*,12R*,13E,15R*)-15-hydroxy-9-oxo-10-oxaprost-13-en-5-ynoate 
• 104221-11-6 7-[(3R,4R)-2-Hydroxy-2-(2-methyl-propane-2-sulfonylmethyl)-4-((E)-1-phenylsulfanyl-oct-2-enyl)-tetrahydro-furan-3-yl]-hept-5-ynoic acid methyl ester 
• 104221-10-5 (1''R*,2''E,2'R*,3'S*,4'S*)-7-<2'-(t-bytylsulfinylmethyl)-2'-hydroxy-4'-(1''-phenylthiooct-2''-enyl)tetrahydrofuran-3'-yl>hept-5-ynoic acid 
• 104221-10-5 (1''R*,2''E,2'S*,3'R*,4'R*)-7-<2'-(t-bytylsulfinylmethyl)-2'-hydroxy-4'-(1''-phenylthiooct-2''-enyl)tetrahydrofuran-3'-yl>hept-5-ynoic acid 
• 104221-10-5 7-[(3R,4R)-2-Hydroxy-2-(2-methyl-propane-2-sulfonylmethyl)-4-((E)-1-phenylsulfanyl-oct-2-enyl)-tetrahydro-furan-3-yl]-hept-5-ynoic acid 

Relevant academic research and scientific papers

A ROUTE TO PROSTAGLANDIN PRECURSORS FROM 1-(PHENYLTHIO)-2-OCTENYLLITHIUM.

The enolates generated by the conjugate addition of 1-(phenylthio)-2-octenyllithium to 4-tert-butoxycyclopent-2-en-1-one and γ-crotonolactone react with methyl 7-halohept-5-ynoates in the presence of Ph3SnCl to deliver products which may be converted into prostaglandin precursors.