104221-01-4Relevant academic research and scientific papers
An Extremely Simple Route to a Prostaglandin Precursor: Hexamethylphosphoric-Triamide-Mediated Conjugate Addition of 1-(Phenylthio)oct-2-enyllithium to 4-t-Butoxycyclopent-2-enone and Triphenyltin-Chloride-Assisted Reaction of the Enolate with Methyl 7-Io
Haynes, Richard K.,Lambert, Dale E.,Schober, Paul A.,Turner, Susan G.
, p. 1211 - 1222 (2007/10/02)
Reaction of 4-t-butoxycyclopent-2-enone with (E)-1-(phenylthio)oct-2-enyllithium in tetrahydrofuran containing 1 . 5 equivalents of hexamethylphosphoric triamide at - 78 deg followed by treatment of the resulting enolate with one equivalent of triphenylti
A ROUTE TO PROSTAGLANDIN PRECURSORS FROM 1-(PHENYLTHIO)-2-OCTENYLLITHIUM.
Binns, Malcolm R.,Haynes, Richard K.,Lambert, Dale E.,Schober, Paul A.
, p. 3385 - 3388 (2007/10/02)
The enolates generated by the conjugate addition of 1-(phenylthio)-2-octenyllithium to 4-tert-butoxycyclopent-2-en-1-one and γ-crotonolactone react with methyl 7-halohept-5-ynoates in the presence of Ph3SnCl to deliver products which may be converted into prostaglandin precursors.
