104222-48-2

Upstream product

• 182937-75-3 2-(3-Bromo-2,4,5-trifluoro-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 
• 104222-44-8 3-bromo-2,4,5-trifluorobenzoyl chloride 
• 104222-42-6 3-bromo-2,4,5-trifluorobenzoic acid 
• 125290-72-4 2-(2,4,5-trifluorophenyl)-4,4-dimethyl-2-oxazoline 
• 122-51-0 orthoformic acid triethyl ester 
• 765-30-0 Cyclopropylamine 
• 104222-46-0 ethyl 3-(3-bromo-2,4,5-trifluorophenyl)-3-oxopropanate 

Relevant academic research and scientific papers

The synthesis of 3-bromo-2,4,5-trifluorobenzoic acid and its conversion to 8-bromoquinolonecarboxylic acids

A series of 8-bromo-4-oxo-3-quinolinecarboxylic acids was prepared via the borate ester, 8. The key intermediate in the synthesis of the final products 10a-10d was 3-bromo-2,4,5-trifluorobenzoic acid (3), conveniently prepared in two steps from the known oxazoline, 1. The preparation of 10a-10d is a significant improvement of the literature procedure currently available for the synthesis of these compounds.