182937-75-3Relevant academic research and scientific papers
The synthesis of 3-bromo-2,4,5-trifluorobenzoic acid and its conversion to 8-bromoquinolonecarboxylic acids
Renau, Thomas E.,Sanchez, Joseph P.,Domagala, John M.
, p. 1407 - 1411 (1996)
A series of 8-bromo-4-oxo-3-quinolinecarboxylic acids was prepared via the borate ester, 8. The key intermediate in the synthesis of the final products 10a-10d was 3-bromo-2,4,5-trifluorobenzoic acid (3), conveniently prepared in two steps from the known oxazoline, 1. The preparation of 10a-10d is a significant improvement of the literature procedure currently available for the synthesis of these compounds.
