1042275-05-7

Upstream product

• 109-12-6 2-aminopyrimidine 
• 99-81-0 4-Nitrophenacyl bromide 

Downstream Products

• 60472-21-1 [4-(4-nitrophenyl)-1H-imidazol-2-yl]amine 
• 1574469-00-3 (S)-2-amino-4-(4-(pyrrolidin-1-ium-2-carboxamido)phenyl)-1H-imidazol-3-ium chloride 
• 1574306-29-8 tert-butyl (S)-2-amino-4-(4-(1-(tert-butoxycarbonyl)pyrrolidine-2-carboxamido)phenyl)-1H-imidazole-1-carboxylate 
• 1574306-28-7 tert-butyl (R)-2-amino-4-(4-(1-(tert-butoxycarbonyl)pyrrolidine-2-carboxamido)phenyl)-1H-imidazole-1-carboxylate 
• 1574306-45-8 4-(4-(1H-indole-2-carboxamido)phenyl)-2-amino-1H-imidazol-3-ium chloride 
• 1574306-25-4 tert-butyl 4-(4-(1H-indole-2-carboxamido)phenyl)-2-amino-1H-imidazole-1-carboxylate 
• 1574306-23-2 tert-butyl 2-amino-4-(4-(furan-2-carboxamido)phenyl)-1H-imidazole-1-carboxylate 
• 1574306-21-0 tert-butyl 4-(4-(1H-pyrrole-2-carboxamido)phenyl)-2-amino-1H-imidazole-1-carboxylate 
• 1574306-18-5 tert-butyl 2-amino-4-(4-aminophenyl)-1H-imidazole-1-carboxylate 
• 1574306-16-3 tert-butyl 2-amino-4-(4-nitrophenyl)-1H-imidazole-1-carboxylate 
• 1574306-44-7 4-(4-(1H-pyrrole-2-carboxamido)phenyl)-2-amino-1H-imidazol-3-ium chloride 

Relevant academic research and scientific papers

Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2- aminoimidazoles as voltage-gated sodium channel modulators

Voltage-gated sodium channels play an integral part in neurotransmission and their dysfunction is frequently a cause of various neurological disorders. On the basis of the structure of marine alkaloid clathrodin, twenty eight new analogs were designed, sy

A divergent synthesis of substituted 2-aminoimidazoles from 2-aminopyrimidines

(Chemical Equation Presented) A new divergent and efficient synthesis of substituted 2-aminoimidazoles 5 and 6 has been developed starting from the readily available 2-aminopyrimidines 1 and α-bromocarbonyl compounds 2, using conventional heating or microwave irradiation. Thus, the cleavage of 1,2,3-substituted imidazo[1,2-a]pyrimidin-1-ium salts 4 with hydrazine or secondary amines led to 1,4,5-trisubstituted 2-aminoimidazoles 5, when the hydrazinolysis of 2-hydroxy-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium salts 3, followed by a novel Dimroth-type rearrangement, resulted in formation of 2-amino-1H-imidazoles 6. The relevant pathway of transformations was identified by characterization of the intermediates.