1042308-64-4

Upstream product

• 1493-27-2 ortho-nitrofluorobenzene 
• 106-40-1 4-bromo-aniline 
• 5467-74-3 4-Bromophenylboronic acid 
• 1038374-09-2 1-(4-bromophenyl)-1H-benzo[d]imidazol-2-amine 
• 100953-52-4 N¹-(4-bromophenyl)benzene -1,2 -diamine 
• 58476-59-8 4-bromo-N-(2-nitrophenyl)benzenamine 
• 888282-88-0 N-(4-bromo-phenyl)-N'-(2-iodo-phenyl)-urea 

Downstream Products

• 1352219-18-1 1-(4-bromo-phenyl)-2-chloro-1H-benzoimidazole 
• 1352874-63-5 [1-(4-bromo-phenyl)-1H-benzoimidazol-2-yl]-cyclopropyl-amine 
• 1352874-62-4 N-[5-chloro-4'-(2-cyclopropylamino-benzoimidazol-1-yl)-biphenyl-2-yl]-acetamide 
• 1352873-93-8 N-{5-chloro-4'-[2-cyclopropylimino-3-(1H-indol-4-ylmethyl)-2,3-dihydro-benzoimidazol-1-yl]-biphenyl-2-yl}-acetamide 

Relevant academic research and scientific papers

Benzimidazolone derivatives organic light emitting compound and organic electroluminescent device including the same

Provided is a benzo imidazolone derivative organic electroluminescent compound represented by chemical formula a. Chemical Formula a. The benzo imidazolone derivative organic light emitting compound is suitable for inclusion in an organic electroluminescent device. Both electrochemical stability and thermal stability can be satisfactorily met.

Selenium-Catalyzed Carbonylative Synthesis of 2-Benzimidazolones from 2-Nitroanilines with TFBen as the CO Source

A selenium-catalyzed carbonylative reaction for the synthesis of 2-benzimidazolones from 2-nitroanilines has been developed. In this strategy, to avoid the usage of toxic CO gas, TFBen (benzene-1,3,5-triyl triformate) was used as a solid and stable CO precursor, and a variety of desired 2-benzimidazolones were produced in moderate to excellent yields.

Chan-Lam cross-coupling reaction based on the Cu2S/TMEDA system

A catalyst based on the readily available Cu2S/TMEDA system using a stable copper(I) source was developed for the Chan-Lam cross-coupling reaction. The capability of the catalyst was demonstrated with 1H-benzo[d]imidazol-2(3H)-one, 1H-benzo[d]imidazole, and 1H-imidazole together with electron-deficient, electron-rich, and sterically demanding boronic acids at room temperature in the presence of atmospheric oxygen to give the cross-coupling products in moderate to excellent yields. In addition, the coupling reaction of 1H-benzo[d]imidazole with several pinacol or neopentylglycol boronates indicated further potential of the catalyst. The reaction conditions tolerate the hydroxyl and bromo functional groups. The catalytic system also enables to synthesize the mono-N-substituted anilines from primary aliphatic amines. However, the two model compounds for the secondary and aromatic amines, piperidine and aniline, do not react. Two sterically demanding products with the restricted C–N bond rotation, synthesized by the N-arylation of 1H-benzo[d]imidazol-2(3H)-one with o-tolylboronic acid, enabled to confirm the atropisomers prepared by the Chan-Lam cross-coupling reaction. Furthermore, an example of one-pot Chan-Lam and Suzuki-Miyaura reaction has been reported.

BIPHENYL SUBSTITUTED 1,3-DIHYDRO-BENZOIMIDAZOL-2-YLIDENEAMINE DERIVATIVES

The invention relates to new derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of one or more IGF-1R mediated disorders or diseases

Copper-catalyzed intramolecular cyclization to N-substituted 1,3-dihydrobenzimidazol-2-ones

(Chemical Equation Presented) An efficient and convenient method was developed for preparing N-substituted 1,3-dihydrobenzimidazol-2-ones from Na?2-substituted N-(2-halophenyl)ureas via a CuI/DBU-catalyzed cyclization in DMSO under microwave heating. High yields were obtained and a variety of functional groups were tolerated under these conditions, including Na?2-aryl, alkyl, heterocyclic, various N-(substituted 2-halophenyl) and N-(2-iodopyridyl)ureas. ? 2008 American Chemical Society.