1042442-14-7Relevant articles and documents
Formation of tricyclic [4.3.3.0] adducts between 8-oxoguanosine and tyrosine under conditions of oxidative DNA-protein cross-linking
Xu, Xiaoyun,Fleming, Aaron M.,Muller, James G.,Burrows, Cynthia J.
supporting information; experimental part, p. 10080 - 10081 (2009/02/04)
8-Oxo-7,8-dihydro-2′-deoxyguanosine (OG), a prevalent product of oxidative stress on cellular DNA, is readily further oxidized forming adducts with nucleophiles. In the presence of tyrosine or p-cresol, an unusual tricyclo[4.3.3.0] adduct has been characterized in both nucleoside and oligodeoxynucleotide studies. The adduct is more stable in oligomers than nucleosides and undergoes slow reversion and hydration to spiroiminodihydantoin. Copyright