104253-45-4

Usage

Uses

Used in Pharmaceutical and Chemical Industries:
METHYL 2-CHLORO-4-METHOXYBENZOATE is used as an intermediate in the synthesis of various organic compounds, playing a crucial role in the development of pharmaceutical products and other chemical substances.
Used as a Flavoring Agent:
METHYL 2-CHLORO-4-METHOXYBENZOATE is utilized as a flavoring agent, adding unique taste profiles to different food and beverage products.
Used in Perfume and Fragrance Production:
METHYL 2-CHLORO-4-METHOXYBENZOATE is employed in the production of perfumes and fragrances, contributing to the creation of distinct and appealing scents for various applications.

Upstream product

• 67-56-1 methanol 
• 21971-21-1 2-chloro-4-methoxybenzoic acid 

Downstream Products

• 719274-51-8 2-chloro-4-methoxybenzohydrazide 
• 21971-21-1 2-chloro-4-methoxybenzoic acid 
• 857599-70-3 2-(2,4-dihydroxy-phenoxy)-4-methoxy-benzoic acid 
• 723285-80-1 4-methoxy-2-(2-methoxy-phenoxy)-benzoic acid 
• 411212-20-9 2-(2-hydroxy-phenoxy)-4-methoxy-benzoic acid 
• 112221-58-6 2,3'-Oxy-di-phenol 
• 1655-71-6 (2-methoxy-phenyl)-(3-methoxy-phenyl)-ether 
• 723286-17-7 4-methoxy-2-(2-methoxy-phenoxy)-benzoic acid methyl ester 
• 855950-92-4 2-(2,4-dimethoxy-phenoxy)-4-methoxy-benzoic acid 

Relevant academic research and scientific papers

5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma

Through a phenotypic high-throughput screen using a serum response element luciferase promoter, we identified a novel 5-aryl-1,3,4-oxadiazol-2-ylthiopropionic acid lead inhibitor of Rho/myocardin-related transcription factor (MRTF)/serum response factor (SRF)-mediated gene transcription with good potency (IC50 = 180 nM). We were able to rapidly improve the cellular potency by 5 orders of magnitude guided by sharply defined and synergistic SAR. The remarkable potency and depth of the SAR, as well as the relatively low molecular weight of the series, suggests, but does not prove, that binding to the unknown molecular target may be occurring through a covalent mechanism. The series nevertheless has no observable cytotoxicity up to 100 μM. Ensuing pharmacokinetic optimization resulted in the development of two potent and orally bioavailable anti-fibrotic agents that were capable of dose-dependently reducing connective tissue growth factor gene expression in vitro as well as significantly reducing the development of bleomycin-induced dermal fibrosis in mice in vivo.