104267-14-3

Basic information

• Product Name: (R)-3,3-Dimethyl-2-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-butyric acid methyl ester
• CAS NO: 104267-14-3
• Molecular Weight: 361.361
• Mol File: 104267-14-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-3,3-Dimethyl-2-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-butyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3,3-Dimethyl-2-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-butyric acid methyl ester(104267-14-3)
• EPA Substance Registry System: (R)-3,3-Dimethyl-2-((S)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionylamino)-butyric acid methyl ester(104267-14-3)

Safety Data

• Hazardous Substances Data: 104267-14-3(Hazardous Substances Data)

Upstream product

• 104266-97-9 (3(2S),4S)-3-(2-(N,N'-bis-(t-butoxycarbonyl)hydrazino)-3,3-dimethyl-1-oxobutyl)-4-(phenylmethyl)-2-oxazolidinone 
• 104266-91-3 (S)-4-benzyl-3-(3,3-dimethylbutanoyl)oxazolidin-2-one 
• 7065-46-5 3,3-dimethylbutanoic acid chloride 
• 186581-53-3 diazomethane 
• 20445-33-4 (R)-methoxytrifluoromethylphenylacetyl chloride 
• 104267-12-1 2S-(N,N'-bis-(t-butoxycarbonyl)hydrazino)-3,3-dimethylbutanoic acid, benzyl ester 

Relevant articles and documents

The Asymmetric Synthesis of α-Amino and α-Hydrazino Acid Derivatives via The Stereoselective Amination of Chiral Enolates with Azodicarboxylate Esters.

The utility of azodicarboxylate esters as (+)NH2 and (+)NH-NH2 synthons in highly diastereoselective reactions with chiral carboximide-derived enolates has been demonstrated.The lithium enolates derived from 4-substituted N-acyl 2-oxazolidinones were found to react with di-tert-butyl azodicarboxylate (DBAD) to afford the derived 2-hydrazido carboxylic acid derivetives in yields in excess of 90 percent.The diastereoselectivities of these reactions ranged from 97percent to greater than 99percent.The subsequent transformation of these adducts to both α-hydrazino and α-amino acids in enantiomeric purities in excess of 99percent is described.