1042724-82-2Relevant academic research and scientific papers
Solid-support based total synthesis and stereochemical correction of brunsvicamide A
Walther, Thilo,Arndt, Hans-Dieter,Waldmann, Herbert
, p. 3199 - 3202 (2008)
(Chemical Equation Presented) A total synthesis of the cyanobacterial metabolite brunsvicamide A and the correction of its originally assigned stereochemistry are reported. Key elements were the construction of a urea building block, peptide elongation on solid phase, and on-resin cyclization of the peptide chain, with good overall yield. Detailed structural investigations uncovered that brunsvicamide A features a previously undetected D-lysine residue in its backbone, setting the foundation for all further investigations in this compound class.
